TB-500

TB-500 (Thymosin Beta-4)

TB-500 is a synthetic peptide fragment corresponding to the active region of Thymosin Beta-4 (Tβ4), a ubiquitous 43-amino acid protein found in virtually all nucleated mammalian cells. Tβ4 is one of the most abundant intracellular peptides in the body and plays a central role in actin sequestration, cytoskeletal organisation, and cell migration. TB-500 has been extensively studied in preclinical models for its roles in tissue repair, angiogenesis, and inflammation modulation, making it a widely used research tool in regenerative biology.

Mechanism of Action

TB-500 exerts its biological effects primarily through binding to G-actin monomers via its LKKTETQ actin-binding domain, thereby regulating actin polymerisation and cytoskeletal dynamics. This interaction promotes cell migration and proliferation in endothelial cells, keratinocytes, and myocytes. Additionally, TB-500 has been shown to upregulate matrix metalloproteinases (MMPs), stimulate angiogenesis via VEGF-dependent pathways, and modulate inflammatory cytokine profiles — collectively supporting its investigation in wound healing and tissue regeneration models.

Research Applications

• Actin dynamics, cytoskeletal organisation, and cell migration studies
• Wound healing and tissue regeneration preclinical models
• Angiogenesis and endothelial cell proliferation research
• Cardiac and skeletal muscle repair investigation
• Inflammation modulation and anti-fibrotic research

Specifications

• Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
• Molecular Weight: 4963.5 g/mol
• CAS Number: 77591-33-4
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.