Introduction
Nootropic and cognitive peptides represent a growing area of neuroscience research. These compounds interact with a range of neurological targets including BDNF pathways, GABA receptors, melanocortin receptors, and hepatocyte growth factor (HGF) signalling to modulate cognition, neuroprotection, anxiety, and neuroplasticity in preclinical models.
For research and laboratory use only. Not intended for human or veterinary administration.
Key Research Compounds
Semax
A synthetic heptapeptide analogue of ACTH(4-7). Semax has been extensively studied for its effects on BDNF (brain-derived neurotrophic factor) upregulation, neuroprotection following ischaemic injury, and cognitive enhancement in rodent models. Research has also investigated its role in modulating the dopaminergic and serotonergic systems.
Selank
A synthetic analogue of the endogenous peptide tuftsin (Thr-Lys-Pro-Arg). Selank has demonstrated anxiolytic properties in preclinical models without the sedative effects associated with benzodiazepines. Research has explored its effects on GABA receptor modulation, IL-6 regulation, and memory consolidation.
Selank + Semax Combination
The combination of Selank and Semax is of research interest due to their complementary mechanisms — Semax acting primarily on BDNF and cognitive pathways, while Selank modulates anxiety and immune function. Preclinical models suggest additive neuroprotective effects.
Dihexa
A potent HGF/MET system agonist. Dihexa has demonstrated remarkable pro-cognitive effects in rodent models of Alzheimer’s disease, with research suggesting it may be significantly more potent than BDNF in promoting synaptogenesis. It is among the most potent nootropic compounds currently under laboratory investigation.
Cerebrolysin
A mixture of low-molecular-weight neuropeptides and amino acids derived from porcine brain tissue. Cerebrolysin has been studied extensively in models of neurodegenerative disease, stroke recovery, and traumatic brain injury. Research suggests neurotrophic, neuroprotective, and neuroplasticity-promoting properties.
P21 (P021)
A small peptide derived from CNTF (ciliary neurotrophic factor). P21 has been studied for its ability to promote neurogenesis and reduce tau hyperphosphorylation in Alzheimer’s disease models, without the side effects associated with full-length CNTF.
PE-22-28
A synthetic analogue of spadin, a peptide derived from the TREK-1 potassium channel propeptide. Research has investigated its rapid antidepressant-like effects in rodent models, with a mechanism distinct from classical antidepressants.
Orexin-A
A neuropeptide produced in the hypothalamus that regulates wakefulness, appetite, and energy homeostasis. Research applications include investigation of narcolepsy models, sleep-wake cycle regulation, and metabolic function.
Pinealon
A tripeptide (Glu-Asp-Arg) studied for neuroprotective and geroprotective properties, particularly in models of age-related cognitive decline and oxidative stress in neural tissue.
Adamax
A synthetic nootropic peptide under investigation for cognitive enhancement and neuroprotective properties in preclinical models.
Research Applications
- Alzheimer’s disease and neurodegeneration models
- Stroke and ischaemic brain injury models
- Anxiety and depression models
- Memory consolidation and learning research
- Sleep-wake cycle and narcolepsy research
- Neuroinflammation models
Storage and Handling
Store lyophilised nootropic peptides at −20°C. Reconstitute with bacteriostatic water unless otherwise specified. Once reconstituted, store at 2–8°C and use within 28 days. Protect from light and avoid repeated freeze-thaw cycles.
All products supplied by Vanta Labs are intended strictly for laboratory and research purposes.