Introduction
BPC-157 and TB-500 are among the most extensively studied peptides in the field of tissue repair and regenerative biology. Both compounds have demonstrated significant activity in preclinical models of musculoskeletal injury, wound healing, and inflammation.
For research and laboratory use only. Not intended for human or veterinary administration.
BPC-157 (Body Protection Compound-157)
Background
BPC-157 is a synthetic pentadecapeptide derived from a protective protein found in gastric juice. It consists of 15 amino acids and is stable in both acidic and neutral environments.
Mechanisms of Action
- Angiogenesis: Upregulates VEGF expression, promoting new blood vessel formation at sites of injury.
- Nitric oxide modulation: Modulates the NO system, contributing to vasodilatory and cytoprotective effects.
- Growth factor upregulation: Increases EGF receptor expression and promotes fibroblast migration and proliferation.
- Anti-inflammatory activity: Inhibits pro-inflammatory cytokines including TNF-α and IL-6.
- Tendon and ligament repair: Promotes tendon-to-bone healing in models of Achilles tendon transection and rotator cuff injury.
Research Applications
- Gastrointestinal injury and ulcer models
- Musculoskeletal repair (tendon, ligament, muscle)
- Neurological injury models
- Inflammatory bowel disease models
- Wound healing and skin repair
TB-500 (Thymosin Beta-4 Fragment)
Background
TB-500 is a synthetic analogue of the active region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid peptide. The active fragment (LKKTETQ, amino acids 17–23) is responsible for the majority of biological activity.
Mechanisms of Action
- Actin sequestration: Binds G-actin, regulating actin polymerisation and promoting cell migration — fundamental to wound healing and tissue remodelling.
- Angiogenesis: Promotes new blood vessel formation, enhancing oxygen and nutrient delivery to damaged tissue.
- Anti-inflammatory effects: Downregulates inflammatory mediators and demonstrates anti-fibrotic properties in cardiac and hepatic models.
- Stem cell differentiation: Promotes differentiation of progenitor cells into endothelial cells, supporting vascular repair.
- Cardiac repair: Studied extensively in myocardial infarction models for cardiomyocyte survival and angiogenesis.
Research Applications
- Cardiac injury and myocardial infarction models
- Musculoskeletal repair
- Wound healing and dermal repair
- Neurological repair models
- Ocular surface repair
BPC-157 + TB-500 Combination Research
The combination is of significant research interest due to complementary mechanisms. BPC-157 acts primarily through VEGF and NO pathways, while TB-500 acts through actin regulation and stem cell recruitment. Preclinical data suggests additive or synergistic effects on tissue repair when both peptides are present.
Storage and Handling
Both peptides are supplied lyophilised. Reconstitute with bacteriostatic water. Store lyophilised at −20°C. Once reconstituted, store at 2–8°C and use within 28 days. Protect from light and avoid agitation.
All products supplied by Vanta Labs are intended strictly for laboratory and research purposes.