5-Amino-1MQ

5-Amino-1MQ

5-Amino-1-methylquinoline (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that plays a central role in cellular energy metabolism, epigenetic regulation, and adipogenesis. With a molecular weight of 158.20 g/mol and CAS number 42464-96-0, this compound has attracted significant interest in preclinical metabolic research for its ability to selectively suppress NNMT activity without broad cytotoxicity.

Mechanism of Action

NNMT catalyses the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing S-adenosylhomocysteine (SAH) and 1-methylnicotinamide. By inhibiting this reaction, 5-Amino-1MQ increases intracellular SAM availability, shifting the cellular methylation landscape. In research models, this has been associated with reduced lipid accumulation in white adipocytes, increased expression of genes involved in thermogenesis, and elevated energy expenditure — making it a compound of interest in obesity and metabolic syndrome research.

Research Applications

• NNMT inhibition and adipocyte differentiation studies
• Metabolic rate and energy expenditure modelling
• Adipocyte lipid metabolism and differentiation studies
• Epigenetic methylation pathway investigation
• SAM/SAH ratio modulation studies

Specifications

• Molecular Formula: C₁₀H₁₁IN₂
• Molecular Weight: 286.11 g/mol
• CAS Number: 42464-96-0
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for human use, veterinary use, or consumer use. Not for diagnostic or therapeutic purposes.