GHK-Cu (Copper Peptide)

GHK-Cu (Copper Peptide)

GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is a research-grade naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine, developed for preclinical investigation of wound healing, tissue remodelling, anti-inflammatory signalling, and gene expression regulation. First isolated by Loren Pickart in 1973, GHK-Cu has been extensively studied for its ability to stimulate collagen and glycosaminoglycan synthesis, modulate metalloproteinase activity, and regulate a broad array of genes associated with tissue repair and antioxidant defence.

Mechanism of Action

GHK-Cu acts through multiple mechanisms: it chelates copper(II) ions and delivers them to cells, facilitating copper-dependent enzymatic activity including lysyl oxidase-mediated collagen crosslinking. It modulates the expression of over 4,000 human genes, upregulating pathways involved in tissue repair, anti-inflammatory signalling, and antioxidant defence, while downregulating genes associated with inflammation and cancer progression. GHK-Cu also stimulates the production of collagen, elastin, and glycosaminoglycans, and activates matrix metalloproteinases (MMPs) to facilitate the removal of damaged extracellular matrix components.

Research Applications

• Wound healing and tissue remodelling studies
• Collagen and extracellular matrix synthesis research
• Anti-inflammatory and antioxidant signalling investigation
• Gene expression modulation and epigenetic research
• Copper-dependent enzyme activity and metalloproteinase studies

Specifications

• Molecular Formula: C₁₄H₂₂CuN₆O₄
• CAS Number: 89030-95-5
• Purity: ≥98%
• Molecular Weight: 401.91 g/mol
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

Commonly Stacked With

GHK-Cu is frequently co-investigated with BPC-157 and TB-500 for comprehensive regenerative and tissue repair research. All three are available together in the pre-formulated GLOW Blend (BPC-157 + GHK-Cu + TB-500).

This peptide is supplied as a lyophilised powder and requires reconstitution with Bacteriostatic Water prior to use.

This product is intended for legitimate laboratory and analytical research use only. Not for human use, veterinary use, or consumer use. Not for diagnostic or therapeutic purposes.