GHK-Cu (Copper Peptide

GHK-Cu (Copper Peptide)

GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is a research-grade naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine, developed for preclinical investigation of wound healing, tissue remodelling, anti-inflammatory signalling, and gene expression regulation. First isolated by Loren Pickart in 1973, GHK-Cu has been extensively studied for its ability to stimulate collagen and glycosaminoglycan synthesis, modulate metalloproteinase activity, and regulate a broad array of genes associated with tissue repair and antioxidant defence.

Mechanism of Action

GHK-Cu acts through multiple mechanisms: it chelates copper(II) ions and delivers them to cells, facilitating copper-dependent enzymatic activity including lysyl oxidase-mediated collagen crosslinking. It modulates the expression of over 4,000 human genes, upregulating pathways involved in tissue repair, anti-inflammatory signalling, and antioxidant defence, while downregulating genes associated with inflammation and cancer progression. GHK-Cu also stimulates the production of collagen, elastin, and glycosaminoglycans, and activates matrix metalloproteinases (MMPs) to facilitate the removal of damaged extracellular matrix components.

Research Applications

• Wound healing and tissue remodelling studies
• Collagen and extracellular matrix synthesis research
• Anti-inflammatory and antioxidant signalling investigation
• Gene expression modulation and epigenetic research
• Copper-dependent enzyme activity and metalloproteinase studies

Specifications

• Molecular Formula: C₁₄H₂₂CuN₆O₄
• CAS Number: 89030-95-5
• Purity: ≥98%
• Molecular Weight: 401.91 g/mol
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.