TB-500

TB-500

TB-500 is a synthetic peptide fragment corresponding to the active region of Thymosin Beta-4 (Tβ4), a ubiquitous 43-amino acid protein found in virtually all nucleated mammalian cells. TB-500 is widely used as a research tool in preclinical biology for the study of actin dynamics, cytoskeletal organisation, and cell migration.

Mechanism of Action

TB-500 binds to G-actin monomers via its LKKTETQ actin-binding domain, regulating actin polymerisation and cytoskeletal dynamics. It has been studied in preclinical models for its roles in angiogenesis and cytokine modulation.

Research Applications

• Actin dynamics and cytoskeletal organisation studies
• Cell migration and endothelial cell proliferation research
• Angiogenesis and VEGF-dependent pathway investigation
• Cardiac and skeletal muscle biology research
• Preclinical inflammation modulation studies

Specifications

• Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
• Molecular Weight: 4963.5 g/mol
• CAS Number: 77591-33-4
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

Commonly Stacked With

TB-500 is frequently co-investigated with BPC-157 for synergistic research. The combination is also available as the pre-formulated BPC-157 + TB-500 (Wolverine Stack). For broader research panels, TB-500 is also studied alongside GHK-Cu (Copper Peptide) — all three are available together in the GLOW Blend.

This peptide is supplied as a lyophilised powder and requires reconstitution with Bacteriostatic Water prior to use.

This product is intended for legitimate laboratory and analytical research use only. Not for human use, veterinary use, or consumer use. Not for diagnostic or therapeutic purposes.