Semax

Semax

Semax is a synthetic heptapeptide (MEHFPGP) derived from the ACTH(4-7) sequence, developed in Russia at the Institute of Molecular Genetics. It is a well-characterised neuropeptide analogue with a proline-glycine-proline (PGP) C-terminal extension that confers resistance to enzymatic degradation, significantly extending its biological half-life compared to the parent ACTH fragment. Semax has been extensively studied in preclinical research for its neurotrophic and neuroprotective properties, and is one of the most thoroughly investigated neuropeptides in the Russian scientific literature.

Mechanism of Action

Semax has been studied in preclinical models for its effects on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in the hippocampus and frontal cortex, supporting neuronal survival and synaptic plasticity. It also modulates dopaminergic and serotonergic systems, and has been shown to influence melanocortin receptor signalling via its ACTH-derived sequence. Additionally, Semax has been investigated for its effects on pro-inflammatory cytokine expression and oxidative stress markers in neuronal tissue.

Research Applications

• BDNF and NGF expression, neurotrophin signalling, and neuroplasticity studies
• Cognitive function, memory, and learning preclinical research
• Neuroprotection and ischaemic brain injury modelling
• Dopaminergic and serotonergic neurotransmission investigation
• Neuroinflammation and oxidative stress in CNS research

Specifications

• Molecular Formula: C₃₇H₅₁N₉O₁₀S
• Molecular Weight: 813.9 g/mol
• CAS Number: 80714-61-0
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

Commonly Stacked With

Semax is frequently co-investigated with Selank for complementary neuropeptide research — both are available as a pre-formulated Selank + Semax blend.

This peptide is supplied as a lyophilised powder and requires reconstitution with Bacteriostatic Water prior to use.

This product is intended for legitimate laboratory and analytical research use only. Not for human use, veterinary use, or consumer use. Not for diagnostic or therapeutic purposes.