GHRP-6 Acetate

GHRP-6 Acetate

GHRP-6 Acetate (Growth Hormone-Releasing Peptide-6) is a research-grade synthetic hexapeptide and first-generation ghrelin receptor (GHS-R1a) agonist, developed for preclinical investigation of growth hormone secretion, appetite regulation, and gastric motility. As the prototypical GHRP, GHRP-6 has been extensively characterised in experimental models and remains a key reference compound in GH secretagogue pharmacology, particularly for studies examining the orexigenic and GH-releasing properties of ghrelin receptor activation.

Mechanism of Action

GHRP-6 binds to the ghrelin receptor (GHS-R1a) on pituitary somatotrophs and hypothalamic neurons, stimulating GH release through phospholipase C and protein kinase C signalling cascades. It also binds to the CD36 scavenger receptor, which mediates its pronounced appetite-stimulating (orexigenic) effect — a distinguishing feature compared to later-generation GHRPs. GHRP-6 partially antagonises somatostatin tone and acts synergistically with GHRH to amplify GH pulse amplitude, making it a useful tool for studying the interplay between these two regulatory axes.

Research Applications

• GH secretagogue pharmacology and pituitary function studies
• Ghrelin receptor (GHS-R1a) and CD36 receptor signalling research
• Appetite regulation and orexigenic pathway investigation
• GH/IGF-1 axis and anabolic signalling modelling
• Gastric motility and gastrointestinal function studies

Specifications

• Molecular Formula: C₄₆H₅₆N₁₀O₆ · C₂H₄O₂
• CAS Number: 145177-42-0
• Purity: ≥98%
• Molecular Weight: 1053.20 g/mol
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.