CJC-1295 (With DAC)

CJC-1295 (With DAC)

CJC-1295 (With DAC) is a long-acting synthetic analogue of growth hormone-releasing hormone (GHRH), engineered with a Drug Affinity Complex (DAC) technology that enables covalent binding to serum albumin. This albumin conjugation dramatically extends the peptide's half-life to approximately 6–8 days, enabling sustained, non-pulsatile elevation of growth hormone levels in research models. It is used in preclinical studies investigating chronic GH/IGF-1 axis stimulation and its downstream metabolic and anabolic effects.

Mechanism of Action

CJC-1295 (With DAC) binds to the GHRH receptor on pituitary somatotrophs, stimulating GH synthesis and secretion. The DAC moiety — a maleimidopropionic acid linker — reacts with the free thiol group of Cys34 on serum albumin, forming a stable covalent bond that protects the peptide from enzymatic degradation and renal clearance. This results in a prolonged GH release profile distinct from the pulsatile pattern of the No DAC variant, making it a useful tool for studying the differential effects of tonic versus pulsatile GH secretion.

Research Applications

• Chronic GH/IGF-1 axis stimulation and sustained anabolic signalling studies
• Albumin-binding drug delivery and pharmacokinetic research
• Pulsatile vs. tonic GH secretion comparison modelling
• Body composition, lipolysis, and metabolic regulation investigation
• GHRH receptor pharmacology and long-acting peptide studies

Specifications

• Molecular Formula: C₁₆₅H₂₆₉N₄₇O₄₆
• CAS Number: 863288-34-0
• Purity: ≥98%
• Molecular Weight: 3647.3 g/mol
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

Commonly Stacked With

CJC-1295 (With DAC) is frequently co-investigated with GH secretagogues for synergistic GH axis stimulation. Related peptides include CJC-1295 (No DAC) (pulsatile GHRH analogue), Ipamorelin (selective GHRP), and GHRP-6 Acetate. A pre-formulated blend is also available as CJC-1295 (No DAC) + Ipamorelin.

This peptide is supplied as a lyophilised powder and requires reconstitution with Bacteriostatic Water prior to use.

This product is intended for legitimate laboratory and analytical research use only. Not for human use, veterinary use, or consumer use. Not for diagnostic or therapeutic purposes.