GHRP-6 Acetate

GHRP-6 Acetate

GHRP-6 Acetate (Growth Hormone-Releasing Peptide-6) is a research-grade synthetic hexapeptide and first-generation ghrelin receptor (GHS-R1a) agonist, developed for preclinical investigation of growth hormone secretion, appetite regulation, and gastric motility. As the prototypical GHRP, GHRP-6 has been extensively characterised in experimental models and remains a key reference compound in GH secretagogue pharmacology, particularly for studies examining the orexigenic and GH-releasing properties of ghrelin receptor activation.

Mechanism of Action

GHRP-6 binds to the ghrelin receptor (GHS-R1a) on pituitary somatotrophs and hypothalamic neurons, stimulating GH release through phospholipase C and protein kinase C signalling cascades. It also binds to the CD36 scavenger receptor, which mediates its pronounced appetite-stimulating (orexigenic) effect — a distinguishing feature compared to later-generation GHRPs. GHRP-6 partially antagonises somatostatin tone and acts synergistically with GHRH to amplify GH pulse amplitude, making it a useful tool for studying the interplay between these two regulatory axes.

Research Applications

• GH secretagogue pharmacology and pituitary function studies
• Ghrelin receptor (GHS-R1a) and CD36 receptor signalling research
• Appetite regulation and orexigenic pathway investigation
• GH/IGF-1 axis and anabolic signalling modelling
• Gastric motility and gastrointestinal function studies

Specifications

• Molecular Formula: C₄₆H₅₆N₁₂O₆ ⋅ 3C₂H₄O₂
• CAS Number: 145177-42-0
• Purity: ≥98%
• Molecular Weight: 1053.2 g/mol
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

Commonly Stacked With

GHRP-6 is frequently co-investigated with GHRH analogues for synergistic GH axis stimulation. Related peptides include CJC-1295 (No DAC), CJC-1295 (With DAC), and Ipamorelin (a more selective, later-generation GHRP for comparative studies). A pre-formulated GHRH/GHRP blend is also available as CJC-1295 (No DAC) + Ipamorelin.

GHRP-6 requires reconstitution with Acetic Acid Solution 1% prior to use.

This product is intended for legitimate laboratory and analytical research use only. Not for human use, veterinary use, or consumer use. Not for diagnostic or therapeutic purposes.