Snap-8

Snap-8

Snap-8 (Acetyl Glutamyl Octapeptide-3) is a synthetic octapeptide analogue of the N-terminal sequence of SNAP-25, a protein integral to the SNARE complex that mediates synaptic vesicle fusion at the neuromuscular junction. As an extended variant of the well-studied Snap-7 (Argireline) sequence, Snap-8 has been developed as a cosmetic research compound with enhanced affinity for the SNARE complex binding site. It is supplied here as a lyophilised research compound for in vitro investigation of neuromuscular signalling and cosmetic peptide biology.

Mechanism of Action

Snap-8 competitively inhibits SNARE complex formation by mimicking the N-terminal domain of SNAP-25, thereby interfering with the docking and fusion of acetylcholine-containing synaptic vesicles at the neuromuscular junction. This reduces acetylcholine exocytosis and attenuates the downstream muscle contraction signal. Compared to shorter analogues, Snap-8’s extended octapeptide sequence is hypothesised to confer greater binding affinity and selectivity for the SNARE complex, making it a refined tool for studying neuromodulatory peptide mechanisms in vitro.

Research Applications

• SNARE complex inhibition and neurotransmitter vesicle fusion studies
• Comparative neuromodulatory peptide potency assays
• Acetylcholine release and neuromuscular junction signalling research
• Cosmetic peptide efficacy and skin biology investigation
• In vitro muscle contraction inhibition modelling

Specifications

• Molecular Formula: C₄₁H₇₀N₁₆O₁₆S
• Molecular Weight: 1075.2 g/mol
• CAS Number: 868844-74-0
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.