SLU-PP-332

SLU-PP-332

SLU-PP-332 is a synthetic small-molecule compound developed as a potent pan-agonist of the oestrogen-related receptor (ERR) family, specifically targeting ERRα, ERRβ, and ERRγ. It was developed by researchers at Saint Louis University as a tool compound to investigate the role of ERR signalling in mitochondrial biogenesis, oxidative metabolism, and exercise mimicry. SLU-PP-332 has attracted significant research interest for its capacity to activate transcriptional programmes associated with endurance exercise adaptation, making it a valuable compound in metabolic and mitochondrial biology research.

Mechanism of Action

SLU-PP-332 binds to and activates all three ERR isoforms (α, β, γ), which are orphan nuclear receptors that regulate the transcription of genes involved in oxidative phosphorylation, fatty acid oxidation, and mitochondrial biogenesis. ERR activation drives expression of PGC-1α target genes — including those encoding components of the electron transport chain and TCA cycle enzymes — mimicking the transcriptional response to aerobic exercise. Preclinical studies have demonstrated that SLU-PP-332 increases mitochondrial content, enhances oxidative capacity in skeletal muscle, and improves exercise performance in rodent models without voluntary physical activity.

Research Applications

• ERRα/β/γ agonism and nuclear receptor pharmacology studies
• Mitochondrial biogenesis and PGC-1α pathway investigation
• Oxidative metabolism and fatty acid oxidation research
• Exercise mimicry and skeletal muscle adaptation modelling
• Metabolic disease and obesity preclinical models

Specifications

• Molecular Formula: C₁₈H₁₄N₂O₂
• Molecular Weight: 290.32 g/mol
• CAS Number: 303760-60-3
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.