Matrixyl

Matrixyl (Palmitoyl Pentapeptide-4)

Matrixyl, chemically designated as Palmitoyl Pentapeptide-4 (Pal-Lys-Thr-Thr-Lys-Ser), is a synthetic lipopeptide consisting of a pentapeptide sequence derived from the C-terminal domain of type I procollagen, conjugated to a palmitoyl fatty acid chain to enhance skin penetration and stability. It was developed by Sederma as a cosmetic active ingredient and has been extensively studied in dermatological and cell biology research for its ability to stimulate extracellular matrix (ECM) protein synthesis in fibroblasts. Matrixyl is one of the most widely researched matrikine-type peptides in skin biology and wound healing research.

Mechanism of Action

Matrixyl acts as a matrikine — a peptide fragment derived from ECM proteins that signals to cells to regulate matrix remodelling. The pentapeptide sequence (KTTKS) is a fragment of the type I procollagen α-chain that binds to fibroblast surface receptors, activating TGF-β-like signalling pathways and stimulating the synthesis of collagen I, collagen III, fibronectin, and hyaluronic acid. The palmitoyl conjugation enhances lipophilicity, facilitating membrane interaction and cellular uptake. Matrixyl also modulates matrix metalloproteinase (MMP) activity, influencing ECM turnover and tissue remodelling dynamics, making it a useful tool for studying fibroblast biology, wound healing, and dermal matrix homeostasis.

Research Applications

• Fibroblast ECM synthesis and collagen I/III production studies
• TGF-β pathway modulation and matrikine signalling research
• Wound healing, tissue remodelling, and dermal matrix homeostasis investigation
• Matrix metalloproteinase (MMP) regulation and ECM turnover research
• Skin biology, anti-ageing peptide mechanism, and cosmetic active research

Specifications

• Molecular Formula:  C₃₉H₇₅N₇O₁₀
• Molecular Weight: 802.05 g/mol
• CAS Number: 214047-00-4
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.