HGH Fragment 176-191

HGH Fragment 176-191

HGH Fragment 176-191 is a synthetic peptide corresponding to amino acids 176–191 of the C-terminal region of human growth hormone (hGH), a 16-amino acid sequence that encompasses the lipolytic domain of the GH molecule. It was developed by researchers at Monash University as part of a programme to isolate the fat-metabolising activity of GH from its growth-promoting and diabetogenic effects. HGH Fragment 176-191 retains the lipolytic potency of full-length GH while lacking significant activity at the GH receptor (GHR) for IGF-1 stimulation or insulin resistance induction, making it a selective research tool for studying GH-mediated lipolysis and adipose tissue metabolism.

Mechanism of Action

HGH Fragment 176-191 exerts its lipolytic effects through a mechanism that is distinct from classical GHR-mediated signalling. Unlike full-length GH, which activates the GHR/JAK2/STAT5 pathway to stimulate IGF-1 production and promote growth, HGH Fragment 176-191 does not bind the GHR with significant affinity and does not stimulate IGF-1 secretion. Instead, it is proposed to act via a β-adrenergic-like mechanism, stimulating adenylyl cyclase and cAMP production in adipocytes, which activates hormone-sensitive lipase (HSL) and promotes triglyceride hydrolysis and fatty acid release. It also inhibits lipogenesis by reducing the activity of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), providing a dual mechanism of lipolysis stimulation and lipogenesis inhibition in adipose tissue research models.

Research Applications

• GH lipolytic domain pharmacology and adipocyte lipolysis mechanism studies
• Hormone-sensitive lipase (HSL) activation and triglyceride hydrolysis research
• Lipogenesis inhibition, fatty acid synthase (FAS), and ACC regulation investigation
• Adipose tissue metabolism, body composition, and fat mobilisation preclinical models
• GH fragment biology and structure-activity relationship (SAR) research

Specifications

• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₂S₂
• Molecular Weight: 1817.1 g/mol
• CAS Number:  66004-57-7
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.