Hexarelin Acetate

Hexarelin Acetate

Hexarelin Acetate is a research-grade synthetic hexapeptide and potent ghrelin receptor (GHS-R1a) agonist, developed for preclinical investigation of growth hormone secretion, cardiac function, and neuroendocrine signalling. As one of the most potent GHRPs characterised to date, Hexarelin exhibits a high binding affinity for GHS-R1a and has been studied extensively in experimental models of GH axis regulation, cardioprotection, and hypothalamic-pituitary function.

Mechanism of Action

Hexarelin binds with high affinity to the ghrelin receptor (GHS-R1a) on pituitary somatotrophs and hypothalamic neurons, activating phospholipase C and protein kinase C signalling cascades to stimulate robust GH secretion. It also partially antagonises somatostatin tone, amplifying GH pulse amplitude. Notably, Hexarelin has been shown to bind to CD36 and the growth hormone secretagogue receptor type 1b (GHS-R1b), and preclinical studies have demonstrated direct cardioprotective effects independent of GH release, including attenuation of ischaemia-reperfusion injury and modulation of cardiac contractility via CD36-mediated signalling.

Research Applications

• GH secretagogue pharmacology and pituitary function studies
• Ghrelin receptor (GHS-R1a) signalling and binding affinity research
• Cardioprotection and ischaemia-reperfusion injury modelling
• CD36 receptor signalling and cardiac function investigation
• GH/IGF-1 axis and anabolic signalling studies

Specifications

• Molecular Formula: C₄₇H₅₈N₁₂O₆
• CAS Number: 140703-51-1
• Purity: ≥98%
• Molecular Weight: 887.0 g/mol (acetate salt)
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.