Epithalon

Epithalon

Epithalon (Epitalon) is a research-grade synthetic tetrapeptide analogue of Epithalamin, a natural polypeptide extract of the pineal gland, developed for preclinical investigation of telomere biology, ageing, and neuroendocrine regulation. Originally developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, Epithalon has been studied extensively in experimental models for its ability to activate telomerase, elongate telomeres, and modulate pineal gland function. It is supplied as a lyophilised powder for use in in vitro and in vivo research.

Mechanism of Action

Epithalon is hypothesised to stimulate the expression of telomerase (hTERT), the enzyme responsible for maintaining telomere length in dividing cells, thereby counteracting replicative senescence. It also modulates the secretion of melatonin and other pineal hormones, influencing circadian rhythm regulation and antioxidant defence. Preclinical studies have demonstrated effects on cell cycle regulation, DNA repair, and the expression of genes associated with longevity and stress resistance, making it a key tool compound in experimental gerontology research.

Research Applications

• Telomerase activation and telomere elongation studies
• Cellular senescence and replicative ageing research
• Pineal gland function and melatonin regulation investigation
• Circadian rhythm and neuroendocrine modulation modelling
• DNA repair and longevity gene expression studies

Specifications

• Molecular Formula: C₁₄H₂₂N₄O₉
• CAS Number: 307297-39-8
• Purity: ≥98%
• Molecular Weight: 390.3 g/mol
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.