Dihexa

Dihexa

Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a research-grade nootropic peptide derived from angiotensin IV, developed for preclinical investigation of cognitive function, synaptic plasticity, and neuroregeneration. It is a potent hepatocyte growth factor (HGF) agonist that acts at the MET receptor, and has been shown in experimental models to facilitate the formation of new synaptic connections with a potency several orders of magnitude greater than BDNF. Dihexa is of significant interest in neuroscience research focused on memory, learning, and neurodegenerative disease modelling.

Mechanism of Action

Dihexa acts as a potentiator of HGF signalling at the MET receptor tyrosine kinase, promoting synaptogenesis, dendritic spine formation, and long-term potentiation (LTP) in hippocampal and cortical circuits. It is thought to facilitate the physical association between HGF and its receptor, amplifying downstream signalling cascades involved in neuronal survival, axonal growth, and synaptic remodelling. Unlike many nootropic compounds, Dihexa's mechanism is distinct from cholinergic or glutamatergic modulation, making it a valuable tool for studying alternative pathways of cognitive enhancement.

Research Applications

• Synaptogenesis and dendritic spine formation studies
• HGF/MET receptor signalling and neuroplasticity research
• Long-term potentiation (LTP) and memory consolidation investigation
• Neurodegenerative disease modelling (Alzheimer's, Parkinson's)
• Cognitive function and learning enhancement studies

Specifications

• Molecular Formula: C₂₇H₄₄N₄O₅
• CAS Number: 1401708-83-5
• Purity: ≥98%
• Molecular Weight: 591.8 g/mol
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.