Cerebrolysin

Cerebrolysin

Cerebrolysin is a research-grade neuropeptide mixture derived from purified porcine brain proteins, developed for preclinical investigation of neurotrophic signalling, neuroprotection, and cognitive function. It contains a defined mixture of low-molecular-weight peptides and free amino acids that mimic the activity of endogenous neurotrophic factors, including BDNF, NGF, CNTF, and GDNF. Cerebrolysin has been extensively studied in experimental models of neurodegeneration, stroke, and traumatic brain injury.

Mechanism of Action

Cerebrolysin exerts its neurotrophic effects through multiple mechanisms, including upregulation of BDNF and NGF expression, inhibition of calpain-mediated neuronal apoptosis, reduction of amyloid precursor protein processing, and modulation of tau phosphorylation. Its constituent peptides penetrate the blood-brain barrier and act directly on neuronal and glial cells to promote survival, differentiation, and synaptic plasticity. Research has demonstrated effects on cholinergic, dopaminergic, and glutamatergic neurotransmitter systems in preclinical models.

Research Applications

• Neurotrophic factor signalling and neuronal survival studies
• Neurodegeneration and Alzheimer's disease modelling
• Neuronal apoptosis and neuroprotective signalling studies
• Synaptic plasticity and cognitive function investigation
• Tau phosphorylation and amyloid processing studies

Specifications

• Molecular Formula: Peptide mixture
• CAS Number: 12656-61-0
• Purity: ≥98%
• Form: Lyophilised extract
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for human use, veterinary use, or consumer use. Not for diagnostic or therapeutic purposes.