ARA-290

ARA-290

ARA-290 is a synthetic 11-amino acid peptide derived from the helix B surface of erythropoietin (EPO), specifically engineered to activate the innate repair receptor (IRR) — a heterodimer of the EPO receptor and the β common receptor (βcR) — without stimulating erythropoiesis or haematopoietic effects. It has been investigated in preclinical and early clinical research for its effects on cytoprotective, anti-inflammatory, and neuroprotective signalling pathways.

Mechanism of Action

ARA-290 selectively binds to the innate repair receptor (IRR), expressed on non-haematopoietic tissues including neurons, pancreatic β-cells, and immune cells. IRR activation has been studied in preclinical models for its effects on PI3K/Akt and JAK2/STAT3 signalling cascades. Unlike full-length EPO, ARA-290 does not bind the classical homodimeric EPO receptor responsible for red blood cell production, making it a selective research tool for studying IRR signalling independent of erythropoietic activity.

Research Applications

• Innate repair receptor (IRR) biology and signalling studies
• Neuroprotection and peripheral neuropathy preclinical research
• Pancreatic β-cell biology and diabetes preclinical modelling
• Anti-inflammatory signalling pathway research
• EPO-derived peptide pharmacology studies

Specifications

• Molecular Formula: C₅₁H₈₄N₁₆O₂₁
• Molecular Weight: 1257.31 g/mol
• CAS Number: 1208243-50-8
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for human use, veterinary use, or consumer use. Not for diagnostic or therapeutic purposes.