AOD9604

AOD9604

AOD9604 is a synthetic peptide fragment derived from the C-terminus of human growth hormone (hGH), specifically residues 176–191, with a tyrosine residue added at the N-terminus. Unlike full-length hGH, AOD9604 does not stimulate IGF-1 production or promote cell proliferation, making it a highly selective research tool for studying the lipolytic properties of growth hormone independent of its anabolic effects.

Mechanism of Action

AOD9604 mimics the lipolytic region of hGH by stimulating fat breakdown (lipolysis) and inhibiting lipogenesis in adipose tissue. It achieves this through interaction with β-adrenergic receptors and downstream cAMP signalling pathways, without binding to the GH receptor or activating the JAK-STAT pathway. This selectivity has made AOD9604 a subject of significant interest in obesity and metabolic research, where the dissociation of lipolytic and growth-promoting effects is desirable.

Research Applications

• Lipolysis and fat metabolism studies
• Obesity and body composition research
• Growth hormone fragment biology
• Adipose tissue signalling and β-adrenergic receptor studies
• Metabolic syndrome modelling

Specifications

• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂
• Molecular Weight: 1815.1 g/mol
• CAS Number: 221231-10-3
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.