ACE-031

ACE-031

ACE-031 is a synthetic research peptide analogue (CAS 1621169-52-5) designed to mimic the ligand-binding activity of the activin receptor type IIC (ActRIIC) extracellular domain. By binding and neutralising myostatin (GDF-8) and related TGF-β superfamily ligands, ACE-031 has been investigated in preclinical research as a tool for studying the regulation of skeletal muscle mass and neuromuscular biology.

Mechanism of Action

Myostatin is a potent endogenous inhibitor of skeletal muscle growth. ACE-031 acts as a competitive antagonist, sequestering myostatin and other negative regulators such as GDF-11 and activin A before they can engage endogenous ActRIIC receptors on muscle fibres. This disinhibition of muscle hypertrophy pathways has been demonstrated in research models to increase lean muscle mass and improve functional muscle metrics.

Research Applications

• Myostatin inhibition and skeletal muscle hypertrophy studies
• Neuromuscular disease modelling
• TGF-β superfamily ligand biology research
• Muscle wasting and cachexia investigation
• ActRIIC signalling pathway studies

Specifications

• Molecular Formula: C₁₃₃H₂₂₇N₄₃O₃₃
• Molecular Weight: 2956.5 g/mol
• CAS Number: 1621169-52-5
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.