Retatrutide

Retatrutide

Retatrutide is a synthetic triple agonist peptide targeting the glucagon receptor (GCGR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucose-dependent insulinotropic polypeptide receptor (GIPR) — making it the first triple incretin receptor agonist to enter advanced clinical research. Developed as a next-generation metabolic research compound, retatrutide combines the complementary mechanisms of all three incretin and glucagon pathways to investigate synergistic effects on energy expenditure, appetite regulation, hepatic lipid metabolism, and body weight. It is supplied here as a lyophilised research compound for in vitro and preclinical investigation.

Mechanism of Action

Retatrutide simultaneously activates GLP-1R, GIPR, and GCGR — all G-protein-coupled receptors signalling via cAMP. GLP-1R activation enhances glucose-dependent insulin secretion and suppresses appetite via hypothalamic pathways; GIPR activation provides additional insulinotropic effects and may modulate adipose tissue metabolism; GCGR activation stimulates hepatic glucose output, promotes lipolysis, and increases energy expenditure through thermogenic mechanisms. The triple agonism is hypothesised to produce additive or synergistic metabolic effects exceeding those of dual agonists, making retatrutide a key tool for studying multi-receptor incretin pharmacology and metabolic regulation.

Research Applications

• Triple GLP-1R/GIPR/GCGR pharmacology and receptor crosstalk studies
• Energy expenditure, thermogenesis, and adipose tissue metabolism research
• Hepatic lipid metabolism and NAFLD/NASH preclinical models
• Appetite regulation and hypothalamic energy homeostasis investigation
• Obesity, body composition, and metabolic syndrome research

Specifications

• Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈
• Molecular Weight: 4731.4 g/mol
• CAS Number: 2381089-83-2
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.