PEG MGF

PEG MGF (PEGylated Mechano Growth Factor)

PEG MGF is a PEGylated synthetic analogue of Mechano Growth Factor (MGF), a splice variant of the IGF-1 gene that is expressed in response to mechanical loading and tissue damage. The polyethylene glycol (PEG) modification significantly extends the plasma half-life of the native MGF peptide from minutes to several days, enabling sustained receptor engagement and making it a more practical tool for preclinical research. PEG MGF has been studied in preclinical models for its roles in muscle satellite cell activation, tissue repair, and anabolic signalling, distinct from the systemic IGF-1 pathway.

Mechanism of Action

MGF is generated by alternative splicing of the IGF-1 gene following mechanical stress or tissue injury, and signals through a distinct receptor pathway from mature IGF-1. The MGF E-domain peptide activates muscle satellite cells (myogenic stem cells), promoting their proliferation and differentiation into new myofibres — a process critical for muscle repair and hypertrophy. PEGylation of the MGF peptide prevents rapid enzymatic degradation, extending its biological activity and enabling investigation of sustained MGF receptor signalling in vitro and in preclinical models. PEG MGF does not bind the IGF-1 receptor with the same affinity as mature IGF-1, making it a selective tool for studying the MGF-specific signalling axis.

Research Applications

• Muscle satellite cell activation, proliferation, and myogenic differentiation studies
• Mechano-sensitive IGF-1 splice variant signalling research
• Skeletal muscle repair and regeneration preclinical models
• Anabolic signalling and muscle hypertrophy investigation
• PEGylation pharmacokinetics and half-life extension research

Specifications

• Molecular Formula: C₁₂₁H₂₀₀N₄₂O₃₉
• Molecular Weight: 2867.20 g/mol
• CAS Number: 108174-48-7
• Purity: ≥98%
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.