HCG

HCG (Human Chorionic Gonadotropin)

HCG (Human Chorionic Gonadotropin) is a research-grade recombinant glycoprotein hormone structurally homologous to luteinising hormone (LH), developed for preclinical investigation of gonadal steroidogenesis, Leydig cell function, and reproductive endocrinology. Endogenously produced by the syncytiotrophoblast during early pregnancy, HCG acts as a potent LH receptor agonist and is widely used in experimental models of testosterone biosynthesis, spermatogenesis, and HPG axis regulation.

Mechanism of Action

HCG binds to the LH/hCG receptor (LHCGR) on Leydig cells in the testes and theca cells in the ovary, activating adenylyl cyclase via Gs protein coupling and increasing intracellular cAMP. This triggers the StAR protein-mediated transport of cholesterol into the mitochondria and the subsequent enzymatic cascade of steroidogenesis, culminating in testosterone (in males) or oestradiol and progesterone (in females) production. HCG also supports Sertoli cell function and spermatogenesis indirectly through testosterone-mediated signalling, and has been studied for its role in luteal phase support and corpus luteum maintenance.

Research Applications

• Leydig cell steroidogenesis and testosterone biosynthesis studies
• LH/hCG receptor (LHCGR) signalling research
• HPG axis regulation and gonadotropin biology investigation
• Spermatogenesis and male reproductive endocrinology modelling
• Ovarian function, luteal phase, and corpus luteum research

Specifications

• Molecular Formula: C₁₁₀₅H₁₇₇₀N₃₁₈O₃₃₆S₂₆
• CAS Number: 9002-61-3
• Purity: ≥98%
• Molecular Weight: ~36,700 Da (glycosylated)
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.