Gonadorelin

Gonadorelin

Gonadorelin is a research-grade synthetic decapeptide identical in structure to endogenous gonadotropin-releasing hormone (GnRH), developed for preclinical investigation of the hypothalamic-pituitary-gonadal (HPG) axis, reproductive endocrinology, and pituitary gonadotroph function. As the native GnRH sequence, Gonadorelin stimulates the pulsatile release of luteinising hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary, making it a key tool compound for studying gonadotropin regulation, fertility biology, and sex steroid feedback mechanisms.

Mechanism of Action

Gonadorelin binds to GnRH receptors (GnRHR) on pituitary gonadotroph cells, activating Gq/11-coupled phospholipase C signalling and triggering intracellular calcium release and protein kinase C activation. This leads to the synthesis and pulsatile secretion of LH and FSH, which in turn stimulate gonadal steroidogenesis and gametogenesis. The pulsatile nature of GnRH signalling is critical: continuous exposure leads to receptor downregulation and gonadotropin suppression, while pulsatile administration maintains or stimulates the HPG axis — a distinction of significant research relevance.

Research Applications

• HPG axis regulation and gonadotropin secretion studies
• GnRH receptor signalling and pituitary gonadotroph biology
• LH and FSH pulsatility and reproductive endocrinology research
• Gonadal steroidogenesis and sex hormone feedback investigation
• Fertility biology and gametogenesis modelling

Specifications

• Molecular Formula: C₅₅H₇N₁₇O₁₃
• CAS Number: 33515-09-2
• Purity: ≥98%
• Molecular Weight: 1182.3 g/mol
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.