GHRP-2 Acetate

GHRP-2 Acetate

GHRP-2 Acetate (Growth Hormone-Releasing Peptide-2) is a research-grade synthetic hexapeptide and potent ghrelin receptor (GHS-R1a) agonist, developed for preclinical investigation of growth hormone secretion, appetite regulation, and metabolic signalling. As a second-generation GHRP, GHRP-2 exhibits greater GH-releasing potency than GHRP-6 with a comparatively reduced orexigenic effect, making it a widely used tool compound in GH axis research and neuroendocrine pharmacology.

Mechanism of Action

GHRP-2 binds to and activates the ghrelin receptor (GHS-R1a) on pituitary somatotrophs and hypothalamic neurons, stimulating GH release through a mechanism distinct from and complementary to GHRH. It activates phospholipase C and protein kinase C signalling cascades, increasing intracellular calcium and triggering GH secretion. GHRP-2 also partially antagonises somatostatin tone, further amplifying GH pulse amplitude. Unlike GHRP-6, GHRP-2 has a lower affinity for the CD36 receptor, resulting in a reduced appetite-stimulating effect while maintaining robust GH secretagogue activity.

Research Applications

• GH secretagogue pharmacology and pituitary function studies
• Ghrelin receptor (GHS-R1a) signalling research
• GH/IGF-1 axis and anabolic signalling investigation
• Somatostatin antagonism and GH pulse modulation
• Appetite regulation and metabolic signalling research

Specifications

• Molecular Formula: C₄₅H₅₅N₉O₆ · C₂H₄O₂
• CAS Number: 158861-67-7
• Purity: ≥98%
• Molecular Weight: 817.9 g/mol (acetate salt)
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.