DSIP

DSIP (Delta Sleep-Inducing Peptide)

DSIP (Delta Sleep-Inducing Peptide) is a research-grade neuropeptide originally isolated from rabbit cerebral venous blood during slow-wave sleep, developed for preclinical investigation of sleep regulation, stress response, and neuroendocrine function. As a naturally occurring nonapeptide, DSIP has been studied for its modulatory effects on sleep architecture, hypothalamic-pituitary-adrenal (HPA) axis activity, and nociception in experimental models. It is supplied as a lyophilised powder for use in in vitro and in vivo research.

Mechanism of Action

DSIP is hypothesised to act on multiple receptor systems, including opioid, GABA-B, and sigma receptors, modulating neuronal excitability and neurotransmitter release in sleep-regulatory circuits. It has been shown in preclinical studies to promote delta (slow-wave) sleep, attenuate stress-induced corticotropin release, and exhibit antioxidant and neuroprotective properties. DSIP also appears to modulate the release of LH, GH, and corticotropin, suggesting a broad role in neuroendocrine regulation beyond sleep alone.

Research Applications

• Sleep architecture and slow-wave sleep regulation studies
• HPA axis modulation and stress response research
• Neuroendocrine signalling (LH, GH, ACTH) investigation
• Nociception and pain modulation modelling
• Neuroprotection and antioxidant activity studies

Specifications

• Molecular Formula: C₃₅H₄₈N₁₀O₁₅
• CAS Number: 62568-57-4
• Purity: ≥98%
• Molecular Weight: 848.9 g/mol
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.