HGH

HGH (Human Growth Hormone / Somatropin)

HGH (Human Growth Hormone, Somatropin) is a research-grade recombinant 191-amino acid polypeptide hormone identical in sequence to endogenous pituitary-derived growth hormone, developed for preclinical investigation of the GH/IGF-1 axis, anabolic signalling, metabolic regulation, and tissue growth. As the primary mediator of somatic growth and a key regulator of protein, lipid, and carbohydrate metabolism, recombinant HGH is a foundational tool compound in endocrinology, metabolic disease research, and regenerative biology.

Mechanism of Action

HGH binds to the growth hormone receptor (GHR), a class I cytokine receptor, inducing receptor dimerisation and activation of the JAK2/STAT5 signalling pathway. This drives the hepatic and peripheral production of insulin-like growth factor 1 (IGF-1), which mediates many of GH's anabolic and mitogenic effects including protein synthesis, cell proliferation, and longitudinal bone growth. GH also exerts direct metabolic effects independent of IGF-1, including lipolysis stimulation, insulin antagonism, and glucose homeostasis modulation. In preclinical models, GH has been studied for its roles in muscle hypertrophy, adipose tissue regulation, immune function, and wound healing.

Research Applications

• GH/IGF-1 axis regulation and somatotroph biology studies
• JAK2/STAT5 signalling and cytokine receptor pharmacology research
• Anabolic signalling, protein synthesis, and muscle biology investigation
• Metabolic regulation, lipolysis, and glucose homeostasis modelling
• Longitudinal bone growth and chondrocyte biology studies

Specifications

• Molecular Formula: C₉₉₀H₁₅₂₈N₂₆₂O₃₀₀S₇
• CAS Number: 12629-01-5
• Purity: ≥98%
• Molecular Weight: 22,124 Da
• Form: Lyophilised powder
• Storage: -20°C
• Shelf Life: 24 months

This product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.