Introduction
Hormonal and fertility-related peptides are central to reproductive endocrinology research. These compounds interact with the hypothalamic-pituitary-gonadal (HPG) axis, gonadotropin receptors, and oxytocin signalling pathways to regulate reproductive function, steroidogenesis, and gonadal activity in preclinical models.
For research and laboratory use only. Not intended for human or veterinary administration.
The HPG Axis
The hypothalamic-pituitary-gonadal axis is the central regulatory system for reproductive function. GnRH (gonadotropin-releasing hormone) is released from the hypothalamus in a pulsatile manner, stimulating the anterior pituitary to release LH (luteinising hormone) and FSH (follicle-stimulating hormone), which in turn act on the gonads to stimulate steroidogenesis and gametogenesis.
Key Research Compounds
HCG (Human Chorionic Gonadotropin)
A glycoprotein hormone that shares structural homology with LH and binds to the LH/hCG receptor. HCG is used extensively in reproductive research as an LH surrogate to stimulate testosterone production in Leydig cells and trigger ovulation in female models. Available in multiple concentrations (1000 IU, 2000 IU, 5000 IU, 10000 IU) for dose-response studies.
HMG (Human Menopausal Gonadotropin)
A preparation containing both FSH and LH activity. HMG is used in research models of follicular stimulation, spermatogenesis, and gonadotropin deficiency states. The combined FSH/LH activity makes it useful for studying synergistic gonadotropin effects on gonadal function.
Gonadorelin (GnRH)
A synthetic decapeptide identical to endogenous GnRH. Gonadorelin stimulates the pulsatile release of LH and FSH from the anterior pituitary. Research applications include investigation of HPG axis function, hypogonadotropic hypogonadism models, and pulsatile GnRH secretion studies. Pulsatile administration stimulates gonadotropin release, while continuous administration causes receptor downregulation and gonadotropin suppression.
Kisspeptin-10
The biologically active C-terminal decapeptide of kisspeptin, a neuropeptide encoded by the KISS1 gene. Kisspeptin acts on GPR54 receptors in the hypothalamus to stimulate GnRH release, making it a key upstream regulator of the HPG axis. Research applications include investigation of puberty onset, GnRH pulse generation, and reproductive senescence models.
Oxytocin Acetate
A nonapeptide neurohormone produced in the hypothalamus and released from the posterior pituitary. Beyond its classical roles in parturition and lactation, oxytocin has been extensively studied for its roles in social bonding, anxiety modulation, pain perception, and cardiovascular function. Research applications span reproductive biology, neuroscience, and psychiatry models.
EPO (Erythropoietin)
A glycoprotein hormone primarily produced by the kidneys in response to hypoxia. EPO stimulates erythropoiesis (red blood cell production) by acting on EPO receptors on erythroid progenitor cells in bone marrow. Research applications include anaemia models, hypoxia response studies, and investigation of EPO receptor signalling in non-haematopoietic tissues including the brain and heart.
Research Applications
- HPG axis regulation and gonadotropin signalling models
- Hypogonadism and gonadotropin deficiency research
- Ovarian stimulation and folliculogenesis models
- Spermatogenesis and male reproductive function research
- Puberty onset and kisspeptin signalling studies
- Social behaviour and oxytocin receptor pharmacology
- Erythropoiesis and anaemia models
- Hypoxia response and EPO receptor signalling research
Storage and Handling
Store lyophilised hormonal peptides at −20°C. HCG and HMG are particularly sensitive to temperature — avoid temperature fluctuations during storage. Reconstitute with bacteriostatic water. Once reconstituted, store at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
All products supplied by Vanta Labs are intended strictly for laboratory and research purposes.