{"product_id":"slu-pp-332","title":"SLU-PP-332","description":"\u003ch2\u003eSLU-PP-332\u003c\/h2\u003e\n\u003cp\u003eSLU-PP-332 is a synthetic small-molecule compound developed as a potent pan-agonist of the oestrogen-related receptor (ERR) family, specifically targeting ERRα, ERRβ, and ERRγ. It was developed by researchers at Saint Louis University as a tool compound to investigate the role of ERR signalling in mitochondrial biogenesis, oxidative metabolism, and exercise mimicry. SLU-PP-332 has attracted significant research interest for its capacity to activate transcriptional programmes associated with endurance exercise adaptation, making it a valuable compound in metabolic and mitochondrial biology research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSLU-PP-332 binds to and activates all three ERR isoforms (α, β, γ), which are orphan nuclear receptors that regulate the transcription of genes involved in oxidative phosphorylation, fatty acid oxidation, and mitochondrial biogenesis. ERR activation drives expression of PGC-1α target genes — including those encoding components of the electron transport chain and TCA cycle enzymes — mimicking the transcriptional response to aerobic exercise. Preclinical studies have demonstrated that SLU-PP-332 increases mitochondrial content, enhances oxidative capacity in skeletal muscle, and improves exercise performance in rodent models without voluntary physical activity.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eERRα\/β\/γ agonism and nuclear receptor pharmacology studies\u003c\/li\u003e\n\u003cli\u003eMitochondrial biogenesis and PGC-1α pathway investigation\u003c\/li\u003e\n\u003cli\u003eOxidative metabolism and fatty acid oxidation research\u003c\/li\u003e\n\u003cli\u003eExercise mimicry and skeletal muscle adaptation modelling\u003c\/li\u003e\n\u003cli\u003eMetabolic disease and obesity preclinical models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₈H₁₄N₂O₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e290.32 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e303760-60-3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103431495944,"sku":"SLUPP-5MG","price":44.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/slu-pp-332_2214bc11-5c3d-47c9-a9db-8a9932adb7f1.png?v=1782894429","url":"https:\/\/vantalabsuk.com\/products\/slu-pp-332","provider":"Vanta Labs","version":"1.0","type":"link"}