{"product_id":"semaglutide","title":"Semaglutide","description":"\u003ch2\u003eSemaglutide\u003c\/h2\u003e\n\u003cp\u003eSemaglutide is a synthetic 31-amino acid GLP-1 receptor agonist peptide with 94% sequence homology to endogenous glucagon-like peptide-1 (GLP-1). It incorporates a C18 fatty diacid chain attached via a linker to lysine at position 26, enabling reversible albumin binding that dramatically extends its plasma half-life to approximately 7 days. Semaglutide is one of the most extensively studied GLP-1 receptor agonists in the research literature, with a substantial body of preclinical and clinical data supporting its investigation in metabolic disease, obesity, and cardiovascular research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSemaglutide binds to and activates the GLP-1 receptor (GLP-1R), a G-protein-coupled receptor expressed on pancreatic beta cells, hypothalamic neurons, and peripheral tissues. GLP-1R activation stimulates glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite via central hypothalamic pathways — particularly through activation of POMC\/CART neurons and inhibition of NPY\/AgRP neurons in the arcuate nucleus. The albumin-binding fatty acid modification confers resistance to DPP-4 degradation and renal clearance, making semaglutide a valuable long-acting tool for studying GLP-1 receptor pharmacology and metabolic regulation.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGLP-1 receptor pharmacology and incretin biology studies\u003c\/li\u003e\n\u003cli\u003eGlucose-dependent insulin secretion and pancreatic beta-cell function research\u003c\/li\u003e\n\u003cli\u003eHypothalamic appetite regulation and energy homeostasis modelling\u003c\/li\u003e\n\u003cli\u003eObesity, body weight regulation, and adipose tissue metabolism investigation\u003c\/li\u003e\n\u003cli\u003eCardiovascular and cardiometabolic disease preclinical models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₈₇H₂₉₁N₄₅O₅₉\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4113.6 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 910463-68-2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103430971656,"sku":"SEMA-2MG","price":11.99,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103431004424,"sku":"SEMA-5MG","price":18.99,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103431037192,"sku":"SEMA-10MG","price":28.99,"currency_code":"GBP","in_stock":true},{"title":"15mg","offer_id":58103431069960,"sku":"SEMA-15MG","price":40.99,"currency_code":"GBP","in_stock":true},{"title":"20mg","offer_id":58103431102728,"sku":"SEMA-20MG","price":58.99,"currency_code":"GBP","in_stock":true},{"title":"30mg","offer_id":58103431135496,"sku":"SEMA-30mg","price":80.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/semaglutide.png?v=1782895227","url":"https:\/\/vantalabsuk.com\/products\/semaglutide","provider":"Vanta Labs","version":"1.0","type":"link"}