{"product_id":"retatrutide","title":"Retatrutide","description":"\u003ch2\u003eRetatrutide\u003c\/h2\u003e\n\u003cp\u003eRetatrutide is a synthetic triple agonist peptide targeting the glucagon receptor (GCGR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucose-dependent insulinotropic polypeptide receptor (GIPR) — making it the first triple incretin receptor agonist to enter advanced clinical research. Developed as a next-generation metabolic research compound, retatrutide combines the complementary mechanisms of all three incretin and glucagon pathways to investigate synergistic effects on energy expenditure, appetite regulation, hepatic lipid metabolism, and body weight. It is supplied here as a lyophilised research compound for in vitro and preclinical investigation.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eRetatrutide simultaneously activates GLP-1R, GIPR, and GCGR — all G-protein-coupled receptors signalling via cAMP. GLP-1R activation enhances glucose-dependent insulin secretion and suppresses appetite via hypothalamic pathways; GIPR activation provides additional insulinotropic effects and may modulate adipose tissue metabolism; GCGR activation stimulates hepatic glucose output, promotes lipolysis, and increases energy expenditure through thermogenic mechanisms. The triple agonism is hypothesised to produce additive or synergistic metabolic effects exceeding those of dual agonists, making retatrutide a key tool for studying multi-receptor incretin pharmacology and metabolic regulation.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTriple GLP-1R\/GIPR\/GCGR pharmacology and receptor crosstalk studies\u003c\/li\u003e\n\u003cli\u003eEnergy expenditure, thermogenesis, and adipose tissue metabolism research\u003c\/li\u003e\n\u003cli\u003eHepatic lipid metabolism and NAFLD\/NASH preclinical models\u003c\/li\u003e\n\u003cli\u003eAppetite regulation and hypothalamic energy homeostasis investigation\u003c\/li\u003e\n\u003cli\u003eObesity, body composition, and metabolic syndrome research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₂₂₁H₃₄₂N₄₆O₆₈\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4731.4 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 2381089-83-2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103430578440,"sku":"RETA-5MG","price":38.99,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103430611208,"sku":"RETA-10MG","price":59.99,"currency_code":"GBP","in_stock":true},{"title":"15mg","offer_id":58103430643976,"sku":"RETA-15MG","price":69.95,"currency_code":"GBP","in_stock":true},{"title":"20mg","offer_id":58103430676744,"sku":"RETA-20MG","price":79.95,"currency_code":"GBP","in_stock":true},{"title":"30mg","offer_id":58103430709512,"sku":"RETA-30MG","price":110.99,"currency_code":"GBP","in_stock":true},{"title":"40mg","offer_id":58103430742280,"sku":"RETA-40MG","price":139.99,"currency_code":"GBP","in_stock":true},{"title":"50mg","offer_id":58103430775048,"sku":"RETA-50MG","price":169.99,"currency_code":"GBP","in_stock":true},{"title":"60mg","offer_id":58103430807816,"sku":"RETA-60MG","price":189.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/retatrutide.png?v=1782895567","url":"https:\/\/vantalabsuk.com\/products\/retatrutide","provider":"Vanta Labs","version":"1.0","type":"link"}