{"product_id":"pnc-27","title":"PNC-27","description":"\u003ch2\u003ePNC-27\u003c\/h2\u003e\n\u003cp\u003ePNC-27 is a synthetic anticancer peptide derived from the MDM-2-binding domain of p53, the tumour suppressor protein. It was developed as a research tool to investigate selective cancer cell membrane disruption, exploiting the differential expression of HDM-2 (the human homologue of MDM-2) on the plasma membranes of cancer cells versus normal cells. PNC-27 has attracted significant preclinical research interest for its proposed mechanism of direct membrane lysis of cancer cells, representing a distinct approach to oncology research compared to conventional intracellular p53-pathway targeting strategies.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003ePNC-27 contains a p53 residue 12-26 sequence fused to a membrane-penetrating leader peptide. It is hypothesised to bind to HDM-2 expressed on the extracellular surface of cancer cell membranes — a phenomenon not observed in normal cells — triggering pore formation and direct membrane disruption leading to necrotic cell death. This mechanism is distinct from apoptosis-inducing agents and does not require intracellular uptake or functional p53 signalling, making PNC-27 a valuable tool for studying cancer cell membrane biology and HDM-2 surface expression in oncology research models.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCancer cell membrane HDM-2 expression and surface biology studies\u003c\/li\u003e\n\u003cli\u003eSelective membrane lysis and pore-forming peptide mechanism research\u003c\/li\u003e\n\u003cli\u003ep53\/MDM-2 interaction and tumour suppressor pathway investigation\u003c\/li\u003e\n\u003cli\u003eIn vitro cancer cell cytotoxicity and selectivity assays\u003c\/li\u003e\n\u003cli\u003eAnticancer peptide design and oncology research models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₈₈H₂₉₃N₅₃O₄₄S\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e4031.72 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e1159861-00-3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eNote:\u003c\/strong\u003e Verify concentration and identity before use in experimental protocols.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"10mg","offer_id":58103430512904,"sku":"PNC27-VER","price":68.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/pnc-27.png?v=1782895895","url":"https:\/\/vantalabsuk.com\/products\/pnc-27","provider":"Vanta Labs","version":"1.0","type":"link"}