{"product_id":"peg-mgf","title":"PEG MGF","description":"\u003ch2\u003ePEG MGF (PEGylated Mechano Growth Factor)\u003c\/h2\u003e\n\u003cp\u003ePEG MGF is a PEGylated synthetic analogue of Mechano Growth Factor (MGF), a splice variant of the IGF-1 gene that is expressed in response to mechanical loading and tissue damage. The polyethylene glycol (PEG) modification significantly extends the plasma half-life of the native MGF peptide from minutes to several days, enabling sustained receptor engagement and making it a more practical tool for preclinical research. PEG MGF has been studied in preclinical models for its roles in muscle satellite cell activation, tissue repair, and anabolic signalling, distinct from the systemic IGF-1 pathway.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eMGF is generated by alternative splicing of the IGF-1 gene following mechanical stress or tissue injury, and signals through a distinct receptor pathway from mature IGF-1. The MGF E-domain peptide activates muscle satellite cells (myogenic stem cells), promoting their proliferation and differentiation into new myofibres — a process critical for muscle repair and hypertrophy. PEGylation of the MGF peptide prevents rapid enzymatic degradation, extending its biological activity and enabling investigation of sustained MGF receptor signalling in vitro and in preclinical models. PEG MGF does not bind the IGF-1 receptor with the same affinity as mature IGF-1, making it a selective tool for studying the MGF-specific signalling axis.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eMuscle satellite cell activation, proliferation, and myogenic differentiation studies\u003c\/li\u003e\n\u003cli\u003eMechano-sensitive IGF-1 splice variant signalling research\u003c\/li\u003e\n\u003cli\u003eSkeletal muscle repair and regeneration preclinical models\u003c\/li\u003e\n\u003cli\u003eAnabolic signalling and muscle hypertrophy investigation\u003c\/li\u003e\n\u003cli\u003ePEGylation pharmacokinetics and half-life extension research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₂₁H₂₀₀N₄₂O₃₉\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e2867.20 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e108174-48-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103430447368,"sku":"PEGMGF-2MG","price":19.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/peg-mgf.png?v=1782896345","url":"https:\/\/vantalabsuk.com\/products\/peg-mgf","provider":"Vanta Labs","version":"1.0","type":"link"}