{"product_id":"pe-22-28","title":"PE-22-28","description":"\u003ch2\u003ePE-22-28\u003c\/h2\u003e\n\u003cp\u003ePE-22-28 is a synthetic heptapeptide analogue of Spadin, a naturally occurring peptide derived from the propeptide of the TREK-1 potassium channel (TRAAK-related K+ channel). Spadin was identified as an endogenous antidepressant peptide that acts as a selective blocker of TREK-1, a two-pore domain (K2P) potassium channel implicated in mood regulation, nociception, and neuroprotection. PE-22-28 was developed as an optimised Spadin analogue with enhanced potency and selectivity for TREK-1, making it a refined research tool for investigating the role of K2P channels in neurological and psychiatric research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003ePE-22-28 selectively inhibits TREK-1 (KCNK2), a mechanosensitive and thermosensitive two-pore domain potassium channel widely expressed in the brain, particularly in regions associated with mood regulation including the hippocampus, prefrontal cortex, and raphe nuclei. TREK-1 blockade reduces the resting membrane hyperpolarisation in serotonergic neurons, increasing their excitability and enhancing serotonin release — a mechanism analogous to, but distinct from, classical antidepressant pharmacology. PE-22-28 has demonstrated rapid-onset antidepressant-like effects in preclinical models, and also promotes hippocampal neurogenesis via BDNF-dependent pathways.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTREK-1 (K2P channel) pharmacology and selective inhibition studies\u003c\/li\u003e\n\u003cli\u003eSerotonergic neuron excitability and mood regulation research\u003c\/li\u003e\n\u003cli\u003eRapid-onset antidepressant mechanism investigation\u003c\/li\u003e\n\u003cli\u003eHippocampal neurogenesis and BDNF signalling research\u003c\/li\u003e\n\u003cli\u003eNociception, mechanosensation, and neuroprotection modelling\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₃₅H₅₅N₁₁O₉\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e773.89 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e1801959-12-5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"10mg","offer_id":58103430414600,"sku":"PE2228-10MG","price":23.9,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/pe-22-28.png?v=1782896530","url":"https:\/\/vantalabsuk.com\/products\/pe-22-28","provider":"Vanta Labs","version":"1.0","type":"link"}