{"product_id":"p21","title":"P21 (P021)","description":"\u003ch2\u003eP21 (P021)\u003c\/h2\u003e\n\u003cp\u003eP21, also designated P021, is a synthetic tetrapeptide (Ac-DGGLAG-NH2 core sequence) derived from the CNTF (Ciliary Neurotrophic Factor) binding domain, specifically designed to mimic the neurotrophic activity of CNTF without engaging the full cytokine receptor complex. It was developed as a research tool to investigate CNTF-like signalling in the context of neurodegeneration, synaptic plasticity, and cognitive function, with particular interest in its potential to modulate tau pathology and promote neurogenesis. P21 has been studied in preclinical models of Alzheimer’s disease and age-related cognitive decline.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eP21 activates the JAK\/STAT3 signalling pathway by mimicking the CNTF binding epitope, promoting the transcription of neurotrophic and neuroprotective genes without the inflammatory side effects associated with full-length CNTF. Preclinical studies have demonstrated that P21 increases hippocampal neurogenesis, enhances dendritic spine density, and reduces hyperphosphorylated tau accumulation in transgenic Alzheimer’s disease models. It also upregulates BDNF expression and promotes synaptic plasticity, supporting its investigation as a tool for studying CNTF-pathway-mediated neuroprotection and cognitive enhancement.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCNTF receptor signalling and JAK\/STAT3 pathway studies\u003c\/li\u003e\n\u003cli\u003eHippocampal neurogenesis and synaptic plasticity research\u003c\/li\u003e\n\u003cli\u003eTau hyperphosphorylation and Alzheimer’s disease preclinical models\u003c\/li\u003e\n\u003cli\u003eBDNF upregulation and neurotrophic signalling investigation\u003c\/li\u003e\n\u003cli\u003eCognitive enhancement and age-related neurodegeneration research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e \u003cspan data-copy-service-computed-style='font-family: \"Google Sans\", Arial, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(230, 232, 240);' data-complete=\"true\" data-sfc-cb=\"\" data-sfc-root=\"ep\" data-sfc-cp=\"\" class=\"T286Pc\"\u003eC₂₇H₄₂N₆O₈\u003c!--TgQPHd||[]--\u003e\u003c\/span\u003e\u003cspan data-copy-service-computed-style='font-family: \"Google Sans\", Arial, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(230, 232, 240);'\u003e\u003c!--TgQPHd||[]--\u003e\u003c\/span\u003e\u003c!--TgQPHd||[]--\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e578.66 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e1246751-68-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103430381832,"sku":"P21-5MG","price":22.9,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/p21.png?v=1782896690","url":"https:\/\/vantalabsuk.com\/products\/p21","provider":"Vanta Labs","version":"1.0","type":"link"}