{"product_id":"orexin-a","title":"Orexin-A","description":"\u003ch2\u003eOrexin-A (Hypocretin-1)\u003c\/h2\u003e\n\u003cp\u003eOrexin-A, also known as Hypocretin-1, is a synthetic 33-amino acid neuropeptide identical in sequence to the endogenous orexin-A produced by a discrete population of neurons in the lateral hypothalamus. It is one of two orexin peptides (alongside Orexin-B\/Hypocretin-2) that act as endogenous ligands for the orexin receptors OX1R and OX2R. Orexin-A has been extensively studied in preclinical research for its roles in arousal, wakefulness, energy homeostasis, reward processing, and autonomic regulation, and is a key research tool in the neuroscience of sleep-wake disorders and narcolepsy.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eOrexin-A binds with high affinity to both OX1R and OX2R — G-protein-coupled receptors (Gq\/11 and Gi\/o) expressed throughout the brain, including the locus coeruleus, dorsal raphe, tuberomammillary nucleus, and basal forebrain. OX1R and OX2R activation promotes the release of noradrenaline, serotonin, histamine, and acetylcholine from wake-promoting nuclei, stabilising the arousal state and suppressing transitions to sleep. Orexin-A also modulates dopaminergic reward circuitry in the ventral tegmental area and nucleus accumbens, and regulates food intake and energy expenditure through hypothalamic circuits.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eOX1R and OX2R pharmacology and orexin receptor signalling studies\u003c\/li\u003e\n\u003cli\u003eArousal, wakefulness, and sleep-wake transition research\u003c\/li\u003e\n\u003cli\u003eNarcolepsy and orexin deficiency preclinical modelling\u003c\/li\u003e\n\u003cli\u003eDopaminergic reward circuitry and addiction neuroscience investigation\u003c\/li\u003e\n\u003cli\u003eEnergy homeostasis, appetite regulation, and autonomic function research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₅₂H₂₄₃N₄₇O₄₄S₄\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 3561.1 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 205640-90-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"10mg","offer_id":58103430250760,"sku":"OREX-10MG","price":198.5,"currency_code":"GBP","in_stock":true},{"title":"20mg","offer_id":58103430283528,"sku":"OREX-20MG","price":299.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/orexin-a.png?v=1782897707","url":"https:\/\/vantalabsuk.com\/products\/orexin-a","provider":"Vanta Labs","version":"1.0","type":"link"}