{"product_id":"mots-c","title":"MOTS-c","description":"\u003ch2\u003eMOTS-c\u003c\/h2\u003e\n\u003cp\u003eMOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondria-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome. It was identified in 2015 by researchers at the University of Southern California as a novel mitochondrial signalling peptide with systemic metabolic regulatory functions. MOTS-c is one of a growing class of mitochondria-derived peptides that act as retrograde signals from the mitochondria to the nucleus and peripheral tissues, and has attracted significant research interest for its roles in metabolic regulation, insulin sensitivity, exercise adaptation, and longevity.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eMOTS-c translocates from the mitochondria to the nucleus in response to metabolic stress, where it regulates nuclear gene expression by interacting with the antioxidant response element (ARE) pathway and activating AMPK signalling. In skeletal muscle, MOTS-c enhances glucose uptake and fatty acid oxidation by promoting GLUT4 translocation and inhibiting the folate cycle — a mechanism that reduces de novo purine synthesis and activates AMPK via AICAR accumulation. MOTS-c also modulates the FOXO1 and NRF2 transcription factors, supporting antioxidant defence and mitochondrial biogenesis, and has demonstrated exercise-mimetic effects in preclinical models.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eMitochondria-derived peptide (MDP) signalling and retrograde communication studies\u003c\/li\u003e\n\u003cli\u003eAMPK activation, glucose metabolism, and insulin sensitivity research\u003c\/li\u003e\n\u003cli\u003eSkeletal muscle metabolic adaptation and exercise mimicry investigation\u003c\/li\u003e\n\u003cli\u003eFolate cycle inhibition and purine biosynthesis regulation research\u003c\/li\u003e\n\u003cli\u003eLongevity, ageing, and mitochondrial function preclinical models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e\n\u003cspan class=\"T286Pc\" data-sfc-cp=\"\" data-sfc-root=\"ep\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Arial, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(230, 232, 240);'\u003eC₁₀₁H₁₅₂N₂₈O₂₂S₂\u003c!--TgQPHd||[]--\u003e\u003c\/span\u003e\u003cspan data-copy-service-computed-style='font-family: \"Google Sans\", Arial, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(230, 232, 240);'\u003e\u003c!--TgQPHd||[]--\u003e\u003c\/span\u003e\u003c!--TgQPHd||[]--\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 2174.5 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 1627580-64-6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103429792008,"sku":"MOTSC-5MG","price":18.0,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103429824776,"sku":"MOTSC-10MG","price":25.0,"currency_code":"GBP","in_stock":true},{"title":"40mg","offer_id":58103429857544,"sku":"MOTSC-40MG","price":59.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/mots-c.png?v=1782914605","url":"https:\/\/vantalabsuk.com\/products\/mots-c","provider":"Vanta Labs","version":"1.0","type":"link"}