{"product_id":"mk-677","title":"MK-677","description":"\u003ch2\u003eMK-677 (Ibutamoren)\u003c\/h2\u003e\n\u003cp\u003eMK-677, also known as Ibutamoren or MK-0677, is a synthetic non-peptide ghrelin receptor agonist and growth hormone secretagogue (GHS) developed by Merck \u0026amp; Co. Unlike peptide-based GHS compounds, MK-677 is orally bioavailable and has a prolonged half-life of approximately 24 hours, making it a practical research tool for sustained GH axis stimulation. It has been extensively studied in preclinical and clinical research for its effects on GH and IGF-1 secretion, body composition, bone density, sleep architecture, and metabolic regulation.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eMK-677 acts as a potent, selective agonist of the ghrelin receptor (GHSR-1a), a G-protein-coupled receptor expressed in the hypothalamus and pituitary. GHSR-1a activation stimulates pulsatile GH release from pituitary somatotrophs via a mechanism that is additive with endogenous GHRH signalling and partially independent of somatostatin inhibition. The resulting GH pulses drive hepatic IGF-1 production, which mediates downstream anabolic, lipolytic, and tissue-remodelling effects. MK-677 also activates hypothalamic neuropeptide Y (NPY) pathways, stimulating appetite — a characteristic feature of ghrelin receptor agonism that is of research interest in cachexia and metabolic disease models.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGhrelin receptor (GHSR-1a) pharmacology and GH secretagogue studies\u003c\/li\u003e\n\u003cli\u003eGH and IGF-1 axis stimulation and somatotropic signalling research\u003c\/li\u003e\n\u003cli\u003eBody composition, lean mass, and adipose tissue metabolism investigation\u003c\/li\u003e\n\u003cli\u003eBone mineral density and skeletal remodelling preclinical models\u003c\/li\u003e\n\u003cli\u003eSleep architecture, REM sleep, and slow-wave sleep research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₂₇H₃₆N₄O₅S • CH₄O₃S\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 624.8 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 159752-10-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103429759240,"sku":"MK677-5MG","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/mk-677.png?v=1782914781","url":"https:\/\/vantalabsuk.com\/products\/mk-677","provider":"Vanta Labs","version":"1.0","type":"link"}