{"product_id":"melanotan-ii","title":"Melanotan II","description":"\u003ch2\u003eMelanotan II\u003c\/h2\u003e\n\u003cp\u003eMelanotan II is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH), developed at the University of Arizona as part of a programme to investigate melanocortin receptor agonists for photoprotection research. It is a non-selective melanocortin receptor agonist with activity at MC1R, MC3R, MC4R, and MC5R, and has been extensively studied in preclinical research for its effects on pigmentation, energy homeostasis, sexual function, and inflammation. Melanotan II is structurally related to PT-141 (Bremelanotide), which is a metabolite formed by hydrolysis of the lactam bridge.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eMelanotan II activates all five melanocortin receptor subtypes (MC1R–MC5R) with varying affinity. MC1R activation on melanocytes stimulates eumelanin synthesis via cAMP-dependent upregulation of tyrosinase, increasing skin pigmentation. MC3R and MC4R activation in the hypothalamus modulates energy balance, appetite suppression, and autonomic nervous system activity — including effects on dopaminergic reward circuitry relevant to sexual arousal research. MC5R activation influences exocrine gland secretion. The broad receptor profile of Melanotan II makes it a useful pharmacological tool for dissecting melanocortin receptor subtype contributions to pigmentation, metabolism, and neuroendocrine regulation.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eMelanocortin receptor (MC1R–MC5R) pharmacology and subtype selectivity studies\u003c\/li\u003e\n\u003cli\u003eMelanogenesis, eumelanin synthesis, and pigmentation biology research\u003c\/li\u003e\n\u003cli\u003eHypothalamic energy homeostasis and appetite regulation investigation\u003c\/li\u003e\n\u003cli\u003eMC4R-mediated autonomic and neuroendocrine signalling research\u003c\/li\u003e\n\u003cli\u003ePhotoprotection and UV-induced DNA damage preclinical models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₅₀H₆₉N₁₅O₉ • xC₂H₄O₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 1024.2 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 121062-08-6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"10mg","offer_id":58103429529864,"sku":"MT2-10MG","price":25.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/melanotan-ii.png?v=1782915174","url":"https:\/\/vantalabsuk.com\/products\/melanotan-ii","provider":"Vanta Labs","version":"1.0","type":"link"}