{"product_id":"mazdutide","title":"Mazdutide","description":"\u003ch2\u003eMazdutide\u003c\/h2\u003e\n\u003cp\u003eMazdutide (IBI362) is a synthetic dual GLP-1R\/GCGR agonist peptide developed by Innovent Biologics as a next-generation metabolic research compound. It combines glucagon-like peptide-1 receptor (GLP-1R) agonism with glucagon receptor (GCGR) agonism in a single molecule, targeting complementary metabolic pathways to investigate synergistic effects on energy expenditure, hepatic lipid metabolism, and body weight regulation. Mazdutide has entered clinical research as a candidate for obesity and metabolic disease, and is supplied here as a research-grade lyophilised compound for preclinical investigation.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eMazdutide simultaneously activates GLP-1R and GCGR — both G-protein-coupled receptors signalling via cAMP. GLP-1R activation enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite via hypothalamic POMC\/CART neuron activation. GCGR activation stimulates hepatic glucose output, promotes lipolysis in adipose tissue, and increases energy expenditure through thermogenic mechanisms including brown adipose tissue (BAT) activation. The dual agonism is designed to leverage the appetite-suppressing and insulinotropic effects of GLP-1R alongside the lipolytic and thermogenic effects of GCGR, producing a complementary metabolic profile of research interest in obesity and NAFLD\/NASH models.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eDual GLP-1R\/GCGR pharmacology and receptor co-activation studies\u003c\/li\u003e\n\u003cli\u003eHepatic lipid metabolism, NAFLD, and NASH preclinical models\u003c\/li\u003e\n\u003cli\u003eEnergy expenditure, thermogenesis, and brown adipose tissue research\u003c\/li\u003e\n\u003cli\u003eAppetite regulation and hypothalamic energy homeostasis investigation\u003c\/li\u003e\n\u003cli\u003eObesity, body composition, and metabolic syndrome research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₂₁₀H₃₂₂N₄₆O₆₇\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e4563.10 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e2259884-03-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103429398792,"sku":"MAZDU-5MG","price":89.99,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103429431560,"sku":"MAZDU-10MG","price":159.99,"currency_code":"GBP","in_stock":true},{"title":"20mg","offer_id":58103429464328,"sku":"MAZDU-20MG","price":310.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/mazdutide.png?v=1782915660","url":"https:\/\/vantalabsuk.com\/products\/mazdutide","provider":"Vanta Labs","version":"1.0","type":"link"}