{"product_id":"ll-37","title":"LL-37","description":"\u003ch2\u003eLL-37\u003c\/h2\u003e\n\u003cp\u003eLL-37 is a 37-amino acid cationic antimicrobial peptide (AMP) and the only known human cathelicidin, derived from the C-terminal domain of the precursor protein hCAP-18 (human cationic antimicrobial protein 18). It is produced by neutrophils, macrophages, mast cells, NK cells, and epithelial cells of the skin, lung, and gastrointestinal tract, and represents a key component of the innate immune system’s first-line defence against microbial pathogens. LL-37 has been extensively studied for its broad-spectrum antimicrobial activity, immunomodulatory functions, wound healing properties, and roles in cancer biology and autoimmune disease.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eLL-37 exerts antimicrobial activity primarily through membrane disruption: its amphipathic α-helical structure enables insertion into bacterial, fungal, and viral lipid membranes, forming pores or inducing membrane lysis via a carpet or toroidal pore mechanism. Beyond direct microbicidal activity, LL-37 modulates innate immune signalling by binding to and neutralising LPS (lipopolysaccharide) and LTA (lipoteichoic acid), preventing TLR4\/TLR2-mediated inflammatory cascades. It also acts as a chemoattractant for neutrophils, monocytes, and T cells via FPRL1 receptor activation, promotes angiogenesis through EGFR and VEGFR signalling, and stimulates keratinocyte migration and proliferation — supporting its investigation in wound healing and tissue repair research.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAntimicrobial peptide (AMP) mechanism, membrane disruption, and pore formation studies\u003c\/li\u003e\n\u003cli\u003eInnate immune modulation, LPS neutralisation, and TLR signalling research\u003c\/li\u003e\n\u003cli\u003eWound healing, keratinocyte migration, and angiogenesis investigation\u003c\/li\u003e\n\u003cli\u003eCathelicidin biology and host defence peptide research\u003c\/li\u003e\n\u003cli\u003eCancer biology, autoimmune disease, and inflammatory signalling models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₂₀₅H₃₄₀N₆₀O₅₃\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4493.3 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 154947-66-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103429333256,"sku":"LL37-5MG","price":29.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/ll-37-redo.png?v=1782916184","url":"https:\/\/vantalabsuk.com\/products\/ll-37","provider":"Vanta Labs","version":"1.0","type":"link"}