{"product_id":"liraglutide","title":"Liraglutide","description":"\u003ch2\u003eLiraglutide\u003c\/h2\u003e\n\u003cp\u003eLiraglutide is a synthetic acylated analogue of human glucagon-like peptide-1 (GLP-1), developed by Novo Nordisk. It shares 97% sequence homology with endogenous GLP-1(7-37) and incorporates a C16 fatty acid chain attached via a glutamic acid linker to Lys26, enabling reversible albumin binding that extends its plasma half-life to approximately 13 hours — significantly longer than native GLP-1 (1–2 minutes). Liraglutide is one of the most extensively studied GLP-1 receptor agonists in metabolic research, with a well-characterised pharmacological profile across glycaemic regulation, body weight, cardiovascular function, and neuroprotection.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eLiraglutide acts as a potent, selective agonist of the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor (Gs) expressed in pancreatic β-cells, hypothalamus, brainstem, heart, kidney, and peripheral tissues. GLP-1R activation stimulates glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite via central POMC\/CART neuron activation and vagal afferent signalling. Liraglutide also activates GLP-1R in the cardiovascular system, promoting cardioprotective effects via cAMP-mediated signalling in cardiomyocytes, and in the brain, where it modulates dopaminergic and inflammatory pathways of research interest in neurodegeneration.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGLP-1 receptor pharmacology and class B GPCR signalling studies\u003c\/li\u003e\n\u003cli\u003eGlucose-dependent insulin secretion and pancreatic β-cell function research\u003c\/li\u003e\n\u003cli\u003eAppetite regulation, hypothalamic energy homeostasis, and obesity investigation\u003c\/li\u003e\n\u003cli\u003eCardiovascular protection and cardiomyocyte GLP-1R signalling research\u003c\/li\u003e\n\u003cli\u003eNeurodegeneration, neuroinflammation, and GLP-1R neuroprotection models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₇₂H₂₆₅N₄₃O₅₁\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 3751.2 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 204656-20-2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103429267720,"sku":"LIRA-5MG","price":79.99,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103429300488,"sku":"LIRA-10MG","price":149.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/liraglutide.png?v=1782916518","url":"https:\/\/vantalabsuk.com\/products\/liraglutide","provider":"Vanta Labs","version":"1.0","type":"link"}