{"product_id":"kisspeptin-10","title":"Kisspeptin-10","description":"\u003ch2\u003eKisspeptin-10\u003c\/h2\u003e\n\u003cp\u003eKisspeptin-10 is a synthetic decapeptide corresponding to the C-terminal 10 amino acids of the kisspeptin family of neuropeptides, which are encoded by the KISS1 gene. Kisspeptins are endogenous ligands of the G-protein-coupled receptor GPR54 (also known as KISS1R), expressed predominantly in the hypothalamus, pituitary, and gonads. Kisspeptin-10 represents the minimal bioactive fragment of the kisspeptin family and is the most potent and widely studied isoform in reproductive neuroendocrinology research. It is a critical regulator of the hypothalamic-pituitary-gonadal (HPG) axis and has been extensively investigated in preclinical and clinical research for its roles in GnRH pulse generation, puberty onset, and fertility regulation.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eKisspeptin-10 acts as a potent agonist of GPR54 (KISS1R), a Gq\/11-coupled receptor expressed on GnRH neurons in the hypothalamic arcuate nucleus (ARC) and anteroventral periventricular nucleus (AVPV). GPR54 activation stimulates phospholipase C (PLC), generating IP3 and DAG, which increase intracellular calcium and activate PKC, leading to membrane depolarisation and GnRH pulse release. GnRH then stimulates pituitary gonadotroph cells to secrete LH and FSH, which drive gonadal steroidogenesis and gametogenesis. Kisspeptin neurons in the ARC also integrate metabolic signals (leptin, insulin, ghrelin) and sex steroid feedback, making the kisspeptin-GPR54 axis a key regulatory node for reproductive function, energy balance, and pubertal timing.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGPR54\/KISS1R pharmacology and GnRH pulse generation studies\u003c\/li\u003e\n\u003cli\u003eHPG axis regulation, LH\/FSH secretion, and gonadotrophin research\u003c\/li\u003e\n\u003cli\u003ePuberty onset, reproductive neuroendocrinology, and fertility investigation\u003c\/li\u003e\n\u003cli\u003eMetabolic-reproductive axis integration and energy balance research\u003c\/li\u003e\n\u003cli\u003eHypogonadotrophic hypogonadism and fertility disorder preclinical models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₆₃H₈₃N₁₇O₁₄\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 1302.5 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e374675-21-5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103428743432,"sku":"KISS-5MG","price":19.9,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103428776200,"sku":"KISS-10MG","price":24.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/kisspeptin-10.png?v=1782920859","url":"https:\/\/vantalabsuk.com\/products\/kisspeptin-10","provider":"Vanta Labs","version":"1.0","type":"link"}