{"product_id":"ipamorelin","title":"Ipamorelin","description":"\u003ch2\u003eIpamorelin\u003c\/h2\u003e\n\u003cp\u003eIpamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) and selective ghrelin receptor agonist, developed by Novo Nordisk as part of a programme to identify GHS compounds with improved selectivity profiles. It is structurally related to GHRP-1 and GHRP-2 but is distinguished by its high selectivity for the GH secretagogue receptor (GHSR-1a) with minimal off-target activity at cortisol, prolactin, or ACTH release pathways — a key pharmacological advantage that makes it a cleaner research tool for studying GH axis stimulation compared to earlier GHRPs. Ipamorelin has been extensively studied in preclinical research for its effects on GH and IGF-1 secretion, body composition, bone density, and gastrointestinal motility.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eIpamorelin acts as a potent, selective agonist of GHSR-1a, the ghrelin receptor expressed in the hypothalamus, pituitary somatotrophs, and peripheral tissues. GHSR-1a activation stimulates pulsatile GH release from pituitary somatotrophs via Gq\/11-mediated phospholipase C activation and intracellular calcium mobilisation, as well as Gi-mediated cAMP modulation. Unlike GHRP-2 and GHRP-6, Ipamorelin does not significantly stimulate cortisol or ACTH release at GH-stimulating doses, and has minimal effect on prolactin secretion, reflecting its high receptor selectivity. The resulting GH pulses drive hepatic IGF-1 production, mediating downstream anabolic, lipolytic, and tissue-remodelling effects. Ipamorelin also acts synergistically with GHRH analogues (such as CJC-1295 or Sermorelin), as the two pathways converge on somatotroph GH release through complementary mechanisms.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGHSR-1a pharmacology and selective GHS receptor agonism studies\u003c\/li\u003e\n\u003cli\u003eGH and IGF-1 axis stimulation and somatotropic signalling research\u003c\/li\u003e\n\u003cli\u003eBody composition, lean mass, and adipose tissue metabolism investigation\u003c\/li\u003e\n\u003cli\u003eBone mineral density and skeletal remodelling preclinical models\u003c\/li\u003e\n\u003cli\u003eGastrointestinal motility and GHS receptor peripheral function research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₃₈H₄₉N₉O₅\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 711.9 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 170851-70-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103428677896,"sku":"IPA-5MG","price":19.95,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103428710664,"sku":"IPA-10MG","price":29.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/ipamorelin.png?v=1782921427","url":"https:\/\/vantalabsuk.com\/products\/ipamorelin","provider":"Vanta Labs","version":"1.0","type":"link"}