{"product_id":"igf-des","title":"IGF-DES","description":"\u003ch2\u003eIGF-DES (Des(1-3)IGF-1)\u003c\/h2\u003e\u003cp\u003eIGF-DES, formally designated Des(1-3)IGF-1, is a naturally occurring truncated isoform of insulin-like growth factor 1 (IGF-1) in which the first three N-terminal amino acids (Gly-Pro-Glu) have been removed. This truncation is generated in vivo by specific proteolytic cleavage in the brain and other tissues, and results in a molecule with markedly altered binding properties compared to full-length IGF-1. IGF-DES has approximately 10-fold lower affinity for IGF-binding proteins (IGFBPs) than full-length IGF-1, while retaining full potency at the IGF-1 receptor (IGF-1R), making it a highly bioavailable and potent research tool for studying IGF-1R-mediated signalling in the absence of IGFBP-mediated sequestration.\u003c\/p\u003e\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\u003cp\u003eIGF-DES acts as a full agonist of the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase that activates the PI3K\/Akt\/mTOR and Ras\/MAPK\/ERK signalling cascades upon ligand binding. These pathways mediate the anabolic, anti-apoptotic, and proliferative effects of IGF-1 signalling in muscle, bone, neural, and other tissues. The critical distinction of IGF-DES from full-length IGF-1 is its dramatically reduced affinity for IGFBPs (particularly IGFBP-3), which normally sequester the majority of circulating IGF-1 and limit its bioavailability. By bypassing IGFBP binding, IGF-DES provides a research tool for studying IGF-1R activation in a context that more closely approximates free, unbound IGF-1 activity, and is particularly useful for investigating local tissue IGF-1 signalling independent of systemic IGFBP regulation.\u003c\/p\u003e\u003ch3\u003eResearch Applications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eIGF-1R pharmacology and receptor tyrosine kinase signalling studies\u003c\/li\u003e\n\u003cli\u003ePI3K\/Akt\/mTOR and MAPK\/ERK pathway activation research\u003c\/li\u003e\n\u003cli\u003eIGFBP-independent IGF-1 signalling and bioavailability investigation\u003c\/li\u003e\n\u003cli\u003eMuscle hypertrophy, satellite cell activation, and anabolic signalling research\u003c\/li\u003e\n\u003cli\u003eNeuroprotection, neurogenesis, and CNS IGF-1R function preclinical models\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e Truncated IGF-1 analogue (Des(1-3)IGF-1)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 7371.4 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 112603-35-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103428645128,"sku":"IGFDES-2MG","price":50.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/igf-des.png?v=1782921946","url":"https:\/\/vantalabsuk.com\/products\/igf-des","provider":"Vanta Labs","version":"1.0","type":"link"}