{"product_id":"igf-1-lr3","title":"IGF-1 LR3","description":"\u003ch2\u003eIGF-1 LR3 (Long R3 IGF-1)\u003c\/h2\u003e\n\u003cp\u003eIGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic recombinant analogue of human IGF-1 incorporating two structural modifications: an N-terminal methionine extension (the “Long” designation) and a glutamic acid-to-arginine substitution at position 3 (the “R3” designation). These modifications were designed to dramatically reduce binding affinity for IGF-binding proteins (IGFBPs) while maintaining full potency at the IGF-1 receptor (IGF-1R). IGF-1 LR3 has approximately 2–3 times the potency of native IGF-1 at IGF-1R and a significantly extended half-life in biological systems due to its reduced IGFBP sequestration, making it one of the most widely used research tools for studying IGF-1R-mediated anabolic and proliferative signalling.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eIGF-1 LR3 acts as a potent full agonist of the IGF-1 receptor (IGF-1R), a heterotetrameric receptor tyrosine kinase. Ligand binding induces receptor autophosphorylation and activation of the insulin receptor substrate (IRS) proteins, initiating downstream signalling through the PI3K\/Akt\/mTOR pathway (mediating protein synthesis, glucose uptake, and anti-apoptotic effects) and the Ras\/MAPK\/ERK pathway (mediating cell proliferation and differentiation). The Arg3 substitution reduces affinity for IGFBP-1, -2, -3, -4, -5, and -6 by approximately 1000-fold compared to native IGF-1, while the N-terminal extension further reduces IGFBP-3 binding. This results in a molecule that is predominantly in the free, bioactive form in biological systems, providing sustained IGF-1R activation that is not attenuated by endogenous IGFBP sequestration.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eIGF-1R pharmacology, receptor tyrosine kinase signalling, and IRS pathway studies\u003c\/li\u003e\n\u003cli\u003ePI3K\/Akt\/mTOR and MAPK\/ERK anabolic signalling research\u003c\/li\u003e\n\u003cli\u003eIGFBP-independent IGF-1 signalling and extended half-life investigation\u003c\/li\u003e\n\u003cli\u003eMuscle hypertrophy, satellite cell biology, and skeletal muscle anabolism research\u003c\/li\u003e\n\u003cli\u003eCell proliferation, differentiation, and anti-apoptotic signalling preclinical models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 9117.5 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 946870-92-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"0.1mg","offer_id":58103428579592,"sku":"IGF1LR3-01MG","price":20.95,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":58103428612360,"sku":"IGF1LR3-1MG","price":39.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/igf-1-lr3.png?v=1782922275","url":"https:\/\/vantalabsuk.com\/products\/igf-1-lr3","provider":"Vanta Labs","version":"1.0","type":"link"}