{"product_id":"humanin","title":"Humanin","description":"\u003ch2\u003eHumanin\u003c\/h2\u003e\n\u003cp\u003eHumanin is a 21-amino acid mitochondria-derived peptide (MDP) encoded within the 16S ribosomal RNA gene of the mitochondrial genome — making it one of the first identified members of the mitochondrial-derived peptide family, alongside MOTS-c and SHLPs. It was originally discovered in 2001 by Nishimoto et al. during a screen for factors that protect neurons from Alzheimer’s disease-associated cell death, and has since been characterised as a pleiotropic cytoprotective peptide with roles in neuroprotection, metabolic regulation, cardiovascular protection, and longevity biology. Humanin circulates in human plasma and declines with age, positioning it as a research target in the biology of ageing and age-related disease.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eHumanin exerts its cytoprotective effects through multiple receptor-dependent and receptor-independent mechanisms. It binds to a tripartite receptor complex comprising gp130, CNTFRα, and WSX-1 on the cell surface, activating JAK2\/STAT3 and PI3K\/Akt signalling pathways that promote cell survival and suppress apoptosis. Humanin also directly interacts with the pro-apoptotic protein BAX, preventing its mitochondrial translocation and cytochrome c release, thereby inhibiting the intrinsic apoptotic pathway. Additionally, Humanin activates AMPK and modulates insulin signalling via the IGF-1 receptor, contributing to its metabolic effects including improved insulin sensitivity and reduced hepatic lipid accumulation. In the CNS, Humanin protects neurons from amyloid-β toxicity, oxidative stress, and ER stress-induced apoptosis, making it a key research tool in neurodegeneration biology.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eMitochondria-derived peptide (MDP) biology and mitochondrial-nuclear communication research\u003c\/li\u003e\n\u003cli\u003eNeuroprotection, amyloid-β toxicity, and Alzheimer’s disease preclinical models\u003c\/li\u003e\n\u003cli\u003eJAK2\/STAT3 and PI3K\/Akt cytoprotective signalling studies\u003c\/li\u003e\n\u003cli\u003eBAX-mediated apoptosis inhibition and mitochondrial integrity research\u003c\/li\u003e\n\u003cli\u003eAgeing biology, longevity, and age-related metabolic disease investigation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e\n\u003cspan class=\"T286Pc\" data-sfc-cp=\"\" data-sfc-root=\"ep\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Arial, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(230, 232, 240);'\u003eC₁₁₉H₂₀₄N₃₄O₃₂S₂\u003c!--TgQPHd||[]--\u003e\u003c\/span\u003e\u003cspan data-copy-service-computed-style='font-family: \"Google Sans\", Arial, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(230, 232, 240);'\u003e\u003c!--TgQPHd||[]--\u003e\u003c\/span\u003e\u003c!--TgQPHd||[]--\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e2687.27 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 330936-69-1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103428481288,"sku":"HUMAN-5MG","price":130.99,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103428514056,"sku":"HUMAN-10MG","price":210.99,"currency_code":"GBP","in_stock":true},{"title":"20mg","offer_id":58103428546824,"sku":"HUMAN-20MG","price":310.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/humanin.png?v=1782922952","url":"https:\/\/vantalabsuk.com\/products\/humanin","provider":"Vanta Labs","version":"1.0","type":"link"}