{"product_id":"hgh-fragment","title":"HGH Fragment 176-191","description":"\u003ch2\u003eHGH Fragment 176-191\u003c\/h2\u003e\n\u003cp\u003eHGH Fragment 176-191 is a synthetic peptide corresponding to amino acids 176–191 of the C-terminal region of human growth hormone (hGH), a 16-amino acid sequence that encompasses the lipolytic domain of the GH molecule. It was developed by researchers at Monash University as part of a programme to isolate the fat-metabolising activity of GH from its growth-promoting and diabetogenic effects. HGH Fragment 176-191 retains the lipolytic potency of full-length GH while lacking significant activity at the GH receptor (GHR) for IGF-1 stimulation or insulin resistance induction, making it a selective research tool for studying GH-mediated lipolysis and adipose tissue metabolism.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eHGH Fragment 176-191 exerts its lipolytic effects through a mechanism that is distinct from classical GHR-mediated signalling. Unlike full-length GH, which activates the GHR\/JAK2\/STAT5 pathway to stimulate IGF-1 production and promote growth, HGH Fragment 176-191 does not bind the GHR with significant affinity and does not stimulate IGF-1 secretion. Instead, it is proposed to act via a β-adrenergic-like mechanism, stimulating adenylyl cyclase and cAMP production in adipocytes, which activates hormone-sensitive lipase (HSL) and promotes triglyceride hydrolysis and fatty acid release. It also inhibits lipogenesis by reducing the activity of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), providing a dual mechanism of lipolysis stimulation and lipogenesis inhibition in adipose tissue research models.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGH lipolytic domain pharmacology and adipocyte lipolysis mechanism studies\u003c\/li\u003e\n\u003cli\u003eHormone-sensitive lipase (HSL) activation and triglyceride hydrolysis research\u003c\/li\u003e\n\u003cli\u003eLipogenesis inhibition, fatty acid synthase (FAS), and ACC regulation investigation\u003c\/li\u003e\n\u003cli\u003eAdipose tissue metabolism, body composition, and fat mobilisation preclinical models\u003c\/li\u003e\n\u003cli\u003eGH fragment biology and structure-activity relationship (SAR) research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₇₈H₁₂₃N₂₃O₂₂S₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 1817.1 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e\n\u003cspan class=\"T286Pc\" data-sfc-cp=\"\" data-sfc-root=\"ep\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Arial, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(230, 232, 240);'\u003e 66004-57-7\u003c!--TgQPHd||[]--\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103428284680,"sku":"HGHFRAG-2MG","price":22.5,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103428317448,"sku":"HGHFRAG-5MG","price":35.9,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103428350216,"sku":"HGHFRAG-10MG","price":62.5,"currency_code":"GBP","in_stock":true},{"title":"12mg","offer_id":58103428382984,"sku":"HGHFRAG-12MG","price":81.5,"currency_code":"GBP","in_stock":true},{"title":"15mg","offer_id":58103428415752,"sku":"HGHFRAG-15MG","price":99.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/hgh-fragment-176-191.png?v=1782932332","url":"https:\/\/vantalabsuk.com\/products\/hgh-fragment","provider":"Vanta Labs","version":"1.0","type":"link"}