{"product_id":"gonadorelin","title":"Gonadorelin","description":"\u003ch2\u003eGonadorelin\u003c\/h2\u003e\u003cp\u003eGonadorelin is a research-grade synthetic decapeptide identical in structure to endogenous gonadotropin-releasing hormone (GnRH), developed for preclinical investigation of the hypothalamic-pituitary-gonadal (HPG) axis, reproductive endocrinology, and pituitary gonadotroph function. As the native GnRH sequence, Gonadorelin stimulates the pulsatile release of luteinising hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary, making it a key tool compound for studying gonadotropin regulation, fertility biology, and sex steroid feedback mechanisms.\u003c\/p\u003e\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\u003cp\u003eGonadorelin binds to GnRH receptors (GnRHR) on pituitary gonadotroph cells, activating Gq\/11-coupled phospholipase C signalling and triggering intracellular calcium release and protein kinase C activation. This leads to the synthesis and pulsatile secretion of LH and FSH, which in turn stimulate gonadal steroidogenesis and gametogenesis. The pulsatile nature of GnRH signalling is critical: continuous exposure leads to receptor downregulation and gonadotropin suppression, while pulsatile administration maintains or stimulates the HPG axis — a distinction of significant research relevance.\u003c\/p\u003e\u003ch3\u003eResearch Applications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eHPG axis regulation and gonadotropin secretion studies\u003c\/li\u003e\n\u003cli\u003eGnRH receptor signalling and pituitary gonadotroph biology\u003c\/li\u003e\n\u003cli\u003eLH and FSH pulsatility and reproductive endocrinology research\u003c\/li\u003e\n\u003cli\u003eGonadal steroidogenesis and sex hormone feedback investigation\u003c\/li\u003e\n\u003cli\u003eFertility biology and gametogenesis modelling\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₅₅H₇N₁₇O₁₃\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 33515-09-2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 1182.3 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103427858696,"sku":"GONADO-2MG","price":14.99,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103427891464,"sku":"GONADO-5MG","price":27.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/gonadorelin.png?v=1782941080","url":"https:\/\/vantalabsuk.com\/products\/gonadorelin","provider":"Vanta Labs","version":"1.0","type":"link"}